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Tbio
ZNF91
Zinc finger protein 91

Protein Summary
Description
Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777). The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300619
  • ENSP00000300619
  • ENSG00000167232
  • ENST00000397082
  • ENSP00000380272

Symbol
  • HPF7
  • HTF10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.69
transcription factor binding site profile
0.66
small molecule perturbation
0.61
gene perturbation
0.59
PubMedID
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.83   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (6)
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999964843
p_ni:  1.65e-7
p_wrong:  0.000034992
Score:  0.225
Data Source:  BioPlex,STRINGDB
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.985337451
p_ni:  4.5e-8
p_wrong:  0.014662504
Data Source:  BioPlex
HTN3
Tbio
Novelty:  0.00825966
Score:  0.904
Data Source:  STRINGDB
ZNF106
Tbio
Novelty:  0.17021565
Score:  0.8
Data Source:  STRINGDB
DSE
Tbio
Family:  Enzyme
Novelty:  0.02945465
Score:  0.539
Data Source:  STRINGDB
LGALS4
Tchem
Novelty:  0.00021923
Score:  0.429
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 91
469069
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 91
Publication Statistics
PubMed Score 19.83
PubMed score by year
PubTator Score 12.02
PubTator score by year
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Related Publications
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PMID
Year
Title