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Tbio
ZNF106
Zinc finger protein 106

Protein Summary
Description
RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263805
  • ENSP00000263805
  • ENSG00000103994
  • ENST00000565380
  • ENSP00000455674

Symbol
  • SH3BP3
  • ZFP106
  • ZNF474
  • SH3BP3
  • ZFP106
  • ZNF474
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
protein domain
0.85
microRNA
0.68
transcription factor
0.68
histone modification site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
KNOP1
Tdark
Novelty:  0.5609503
p_int:  0.999999975
p_ni:  2.1e-8
p_wrong:  4e-9
Score:  0.578
Data Source:  BioPlex,STRINGDB
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.999998874
p_ni:  0.000001126
Score:  0.155
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999984737
p_ni:  0.000015213
p_wrong:  5e-8
Data Source:  BioPlex
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.999984523
p_ni:  0.000015477
Data Source:  BioPlex
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.999977753
p_ni:  0.000022247
Score:  0.187
Data Source:  BioPlex,STRINGDB
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.99996062
p_ni:  0.00003938
Score:  0.16
Data Source:  BioPlex,STRINGDB
FBXL5
Tbio
Novelty:  0.03103624
p_int:  0.99993837
p_ni:  0.00006163
Score:  0.214
Data Source:  BioPlex,STRINGDB
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.999921215
p_ni:  0.00007875
p_wrong:  3.5e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999490257
p_ni:  0.000509688
p_wrong:  5.5e-8
Data Source:  BioPlex
STAMBPL1
Tbio
Family:  Enzyme
Novelty:  0.08532786
p_int:  0.994643507
p_ni:  0.004909688
p_wrong:  0.000446805
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
4
9
7
94.2
monocyte percentage of leukocytes
2
1
2
82.1
IGF-1 measurement
1
1
1
78.4
serum albumin measurement
1
1
1
76.7
high density lipoprotein cholesterol measurement
2
2
2
69.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
7
94.2
monocyte percentage of leukocytes
2
82.1
IGF-1 measurement
1
78.4
serum albumin measurement
1
76.7
high density lipoprotein cholesterol measurement
2
69.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 106
VGNC:1576
467665
Macaque
zinc finger protein 106
708021
Dog
zinc finger protein 106 [Source:HGNC Symbol;Acc:HGNC:12886]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 106
Macaque
zinc finger protein 106
Dog
zinc finger protein 106 [Source:HGNC Symbol;Acc:HGNC:12886]
Publication Statistics
PubMed Score 8.30
PubMed score by year
PubTator Score 2.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title