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Tbio
ZER1
Protein zer-1 homolog

Protein Summary
Description
Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC. This gene encodes a subunit of an E3 ubiquitin ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291900
  • ENSP00000291900
  • ENSG00000160445

Symbol
  • C9orf60
  • ZYG
  • ZYG11BL
  • ZYG
  • C9orf60
  • ZYG11BL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
cell line
0.7
transcription factor binding site profile
0.7
microRNA
0.68
small molecule perturbation
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.93   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.93   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
RTBDN
Tdark
Novelty:  0.13274492
p_int:  0.993503721
p_ni:  0.006496278
Score:  0.189
Data Source:  BioPlex,STRINGDB
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.98265261
p_ni:  0.017346779
p_wrong:  6.11e-7
Data Source:  BioPlex
MRM1
Tbio
Family:  Enzyme
Novelty:  0.08762499
p_int:  0.979079697
p_ni:  0.020920303
Data Source:  BioPlex
SPINK7
Tbio
Family:  Enzyme
Novelty:  0.02397234
p_int:  0.979022995
p_ni:  0.020977005
Data Source:  BioPlex
CUTA
Tbio
Novelty:  0.01771609
p_int:  0.976720146
p_ni:  0.023279854
Score:  0.173
Data Source:  BioPlex,STRINGDB
STMN2
Tbio
Novelty:  0.00854367
p_int:  0.946767572
p_ni:  0.053232428
Data Source:  BioPlex
GOLGA4
Tbio
Novelty:  0.01363253
p_int:  0.944341709
p_ni:  0.05565829
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
STMN3
Tbio
Novelty:  0.05061958
p_int:  0.9433447
p_ni:  0.0566553
Data Source:  BioPlex
WFDC9
Tdark
Novelty:  3.44827586
p_int:  0.927481726
p_ni:  0.072518273
Score:  0.206
Data Source:  BioPlex,STRINGDB
GAST
Tbio
Novelty:  0.00011795
p_int:  0.926736422
p_ni:  0.073263577
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
3
5
93.9
sex hormone-binding globulin measurement
8
1
7
7.4
84.3
low density lipoprotein cholesterol measurement
4
3
4
79.9
platelet crit
2
2
2
79.8
platelet count
2
2
2
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
93.9
sex hormone-binding globulin measurement
7
7.4
84.3
low density lipoprotein cholesterol measurement
4
79.9
platelet crit
2
79.8
platelet count
2
74
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zyg-11 related cell cycle regulator
VGNC:10124
464775
Macaque
zyg-11 related cell cycle regulator
717262
Mouse
MGI:2442511
227693
Rat
RGD:1310284
311842
Dog
zyg-11 related cell cycle regulator
VGNC:48598
491312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zyg-11 related cell cycle regulator
Macaque
zyg-11 related cell cycle regulator
Mouse
Rat
Dog
zyg-11 related cell cycle regulator
Publication Statistics
PubMed Score 25.93
PubMed score by year
PubTator Score 2.25
PubTator score by year
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Related Publications
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PMID
Year
Title