Protein Summary
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM ...more
- ENST00000255305
- ENSP00000255305
- ENSG00000132953
- KIAA1721
- exp4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.88 | ||
transcription factor perturbation | 0.88 | ||
drug perturbation | 0.87 | ||
microRNA | 0.85 | ||
interacting protein | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.22 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 46 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.22 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 46 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (92)
UXS1
Family: Enzyme
Novelty: 0.04671281
p_int: 0.999774541
p_ni: 0.000225459
Data Source: BioPlex
PNKD
Family: Enzyme
Novelty: 0.02456078
p_int: 0.999711153
p_ni: 0.000288847
Data Source: BioPlex
EPHA1
Family: Kinase
Novelty: 0.00136672
p_int: 0.99944383
p_ni: 0.00055617
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
PathwayCommons (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: netpath | TGF_beta_Receptor | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
TGF_beta_Receptor | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 3 | 3 | 69.6 | |||||
cognitive function measurement | 1 | 1 | 1 | 52.7 | |||||
self reported educational attainment | 1 | 1 | 1 | 49.5 | |||||
systolic blood pressure | 1 | 1 | 1 | 38.8 | |||||
intelligence | 1 | 1 | 0 | 5.9 | 31.4 | ||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 69.6 | |||||
cognitive function measurement | 1 | 52.7 | |||||
self reported educational attainment | 1 | 49.5 | |||||
systolic blood pressure | 1 | 38.8 | |||||
intelligence | 0 | 5.9 | 31.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | exportin 4 | VGNC:5134 | 467222 | |||||
Macaque | exportin 4 | 703548 | ||||||
Mouse | MGI:1888526 | 57258 | ||||||
Rat | RGD:1312015 | 290280 | ||||||
Dog | exportin 4 | VGNC:48461 | 477344 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | exportin 4 | |||||
Macaque | exportin 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | exportin 4 | |||||
Publication Statistics
PubMed Score 65.22
PubMed score by year
PubTator Score 28.28
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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