You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
XPO4
Exportin-4

Protein Summary
Description
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255305
  • ENSP00000255305
  • ENSG00000132953

Symbol
  • KIAA1721
  • exp4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor perturbation
0.88
drug perturbation
0.87
microRNA
0.85
interacting protein
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.22   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.22   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
VSIG2
Tdark
Novelty:  0.32398032
p_int:  0.999959876
p_ni:  0.000040124
Data Source:  BioPlex
UXS1
Tbio
Family:  Enzyme
Novelty:  0.04671281
p_int:  0.999774541
p_ni:  0.000225459
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.99973424
p_ni:  0.00026576
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.999711153
p_ni:  0.000288847
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.99970688
p_ni:  0.000293119
p_wrong:  1e-9
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.99944383
p_ni:  0.00055617
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.999073591
p_ni:  0.000926409
Data Source:  BioPlex
CD274
Tclin
Novelty:  0.00013449
p_int:  0.999045264
p_ni:  0.000954736
Data Source:  BioPlex
VASN
Tbio
Novelty:  0.05424159
p_int:  0.997566497
p_ni:  0.002433502
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.996145393
p_ni:  0.003854607
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
69.6
cognitive function measurement
1
1
1
52.7
self reported educational attainment
1
1
1
49.5
systolic blood pressure
1
1
1
38.8
intelligence
1
1
0
5.9
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
69.6
cognitive function measurement
1
52.7
self reported educational attainment
1
49.5
systolic blood pressure
1
38.8
intelligence
0
5.9
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exportin 4
VGNC:5134
467222
Macaque
exportin 4
703548
Mouse
MGI:1888526
57258
Rat
RGD:1312015
290280
Dog
exportin 4
VGNC:48461
477344
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exportin 4
Macaque
exportin 4
Mouse
Rat
Dog
exportin 4
Publication Statistics
PubMed Score 65.22
PubMed score by year
PubTator Score 28.28
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title