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Tdark
WDR55
WD repeat-containing protein 55

Protein Summary
Description
Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358337
  • ENSP00000351100
  • ENSG00000120314
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
protein domain
0.73
transcription factor binding site profile
0.65
disease perturbation
0.56
gene perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.99953969
p_ni:  0.000460308
p_wrong:  2e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
MCMBP
Tbio
Novelty:  0.13330215
p_int:  0.999482539
p_ni:  0.000517461
Data Source:  BioPlex
BOP1
Tbio
Novelty:  0.03512044
p_int:  0.982809171
p_ni:  0.017190829
Score:  0.905
Data Source:  BioPlex,STRINGDB
RPL7L1
Tdark
Novelty:  0.78428937
p_int:  0.944000561
p_ni:  0.055999439
Score:  0.378
Data Source:  BioPlex,STRINGDB
KLHDC3
Tdark
Novelty:  0.63840156
p_int:  0.912898805
p_ni:  0.039481325
p_wrong:  0.04761987
Data Source:  BioPlex
LENG8
Tdark
Novelty:  0.66682078
p_int:  0.910397885
p_ni:  0.089283454
p_wrong:  0.000318661
Score:  0.236
Data Source:  BioPlex,STRINGDB
WDR12
Tbio
Novelty:  0.03409059
p_int:  0.89894471
p_ni:  0.10105529
Score:  0.954
Data Source:  BioPlex,STRINGDB
FTSJ3
Tbio
Family:  Enzyme
Novelty:  0.01888973
p_int:  0.896584573
p_ni:  0.103415427
Score:  0.418
Data Source:  BioPlex,STRINGDB
REXO5
Tdark
Family:  Enzyme
Novelty:  0.8782494
p_int:  0.887581358
p_ni:  0.112391626
p_wrong:  0.000027016
Score:  0.233
Data Source:  BioPlex,STRINGDB
RPL3
Tbio
Novelty:  0.00566964
p_int:  0.883592279
p_ni:  0.116407721
Score:  0.163
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
3
1
5.9
56.4
self reported educational attainment
2
2
2
45.2
household income
1
1
1
24.5
cognitive function measurement
3
1
3
24.5
systolic blood pressure
1
1
1
24.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
5.9
56.4
self reported educational attainment
2
45.2
household income
1
24.5
cognitive function measurement
3
24.5
systolic blood pressure
1
24.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915186
67936
Cow
WD repeat domain 55
VGNC:36906
508709
Zebrafish
ZDB-GENE-040924-7
445394
C. elegans
175547
Fruitfly
FBgn0037943
41419
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Cow
WD repeat domain 55
Zebrafish
C. elegans
Fruitfly
Publication Statistics
PubMed Score 2.97
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title