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Tbio
VSX1
Visual system homeobox 1

Protein Summary
Description
Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development. The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376707
  • ENSP00000365897
  • ENSG00000100987
  • ENST00000376709
  • ENSP00000365899
  • ENST00000409285
  • ENSP00000386612
  • ENST00000409958
  • ENSP00000387069
  • ENST00000429762
  • ENSP00000401690
  • ENST00000444511
  • ENSP00000387720

Symbol
  • RINX
  • PPD
  • KTCN
  • PPCD
  • RINX
  • KTCN1
  • PPCD1
  • CAASDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.63
cell line
0.59
protein domain
0.58
biological process
0.52
phenotype
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.31   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.31   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0