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Tbio
VPS13C
Vacuolar protein sorting-associated protein 13C

Protein Summary
Description
Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization. This gene encodes a member of the vacuolar protein sorting-associated 13 gene family. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249837
  • ENSP00000249837
  • ENSG00000129003
  • ENST00000261517
  • ENSP00000261517
  • ENST00000395896
  • ENSP00000379233
  • ENST00000395898
  • ENSP00000379235
  • ENST00000644861
  • ENSP00000493560
  • ENST00000645819
  • ENSP00000496179

Symbol
  • KIAA1421
  • PARK23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
microRNA
0.87
transcription factor binding site profile
0.85
disease perturbation
0.79
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.05   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.05   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
LGALS12
Tbio
Novelty:  0.05634386
p_int:  0.999961974
p_ni:  0.000037966
p_wrong:  6e-8
Score:  0.847
Data Source:  BioPlex,STRINGDB
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.999914358
p_ni:  0.000085642
Score:  0.214
Data Source:  BioPlex,STRINGDB
UBXN4
Tbio
Novelty:  0.16206743
p_int:  0.99988769
p_ni:  0.00011231
Score:  0.332
Data Source:  BioPlex,STRINGDB
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.999862368
p_ni:  0.000137632
Data Source:  BioPlex
UBTD1
Tdark
Novelty:  0.50393104
p_int:  0.999807776
p_ni:  0.000192224
Data Source:  BioPlex
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
p_int:  0.99882438
p_ni:  0.001175618
p_wrong:  2e-9
Score:  0.401
Data Source:  BioPlex,STRINGDB
IER3IP1
Tbio
Novelty:  0.07401881
p_int:  0.997769546
p_ni:  0.002230451
p_wrong:  3e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.997713738
p_ni:  0.002286262
Score:  0.263
Data Source:  BioPlex,STRINGDB
RAB1A
Tbio
Family:  Enzyme
Novelty:  0.00307527
p_int:  0.995977907
p_ni:  0.004022087
p_wrong:  6e-9
Score:  0.23
Data Source:  BioPlex,STRINGDB
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.992164777
p_ni:  0.007835222
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
4
1.1
93.5
IGF-1 measurement
1
3
3
91
body mass index
3
4
4
68.4
glucose tolerance test
1
1
1
61
body height
2
2
2
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
93.5
IGF-1 measurement
3
91
body mass index
4
68.4
glucose tolerance test
1
61
body height
2
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vacuolar protein sorting 13 homolog C
VGNC:10173
453491
Macaque
vacuolar protein sorting 13 homolog C
709080
Mouse
MGI:2444207
320528
Rat
RGD:1560364
363087
Dog
vacuolar protein sorting 13 homolog C
VGNC:48276
487586
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vacuolar protein sorting 13 homolog C
Macaque
vacuolar protein sorting 13 homolog C
Mouse
Rat
Dog
vacuolar protein sorting 13 homolog C
Publication Statistics
PubMed Score 24.05
PubMed score by year
PubTator Score 8.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title