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Tbio
TXNDC11
Thioredoxin domain-containing protein 11

Protein Summary
Description
May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283033
  • ENSP00000283033
  • ENSG00000153066
  • ENST00000356957
  • ENSP00000349439

Symbol
  • EFP1
  • EFP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.87
virus perturbation
0.72
virus
0.66
cell type or tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
RBL1
Tbio
Novelty:  0.00228265
p_int:  0.999995441
p_ni:  0.000004559
Score:  0.773
Data Source:  BioPlex,STRINGDB
RBL2
Tbio
Novelty:  0.00121893
p_int:  0.999584796
p_ni:  0.000413816
p_wrong:  0.000001388
Score:  0.554
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.99928169
p_ni:  0.00071831
Data Source:  BioPlex
TXLNA
Tbio
Novelty:  0.02549959
p_int:  0.999237925
p_ni:  0.000762075
Data Source:  BioPlex
USO1
Tbio
Novelty:  0.02066669
p_int:  0.997594541
p_ni:  0.002405459
Score:  0.261
Data Source:  BioPlex,STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
p_int:  0.995742706
p_ni:  0.004255897
p_wrong:  0.000001398
Score:  0.64
Data Source:  BioPlex,STRINGDB
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.972572098
p_ni:  0.027427902
Score:  0.887
Data Source:  BioPlex,STRINGDB
CHST8
Tbio
Family:  Enzyme
Novelty:  0.03489772
p_int:  0.965744589
p_ni:  0.034255411
Data Source:  BioPlex
PCNT
Tbio
Novelty:  0.00369505
p_int:  0.96450803
p_ni:  0.03549197
Data Source:  BioPlex
FBLN7
Tbio
Novelty:  0.03423924
p_int:  0.929305797
p_ni:  0.070694201
p_wrong:  2e-9
Score:  0.702
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
2
69
88.6
sex hormone-binding globulin measurement
6
3
6
85.6
QT interval
6
3
2
1.3
79.4
low density lipoprotein cholesterol measurement
4
1
4
75.4
alkaline phosphatase measurement
2
1
1
5.7
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
69
88.6
sex hormone-binding globulin measurement
6
85.6
QT interval
2
1.3
79.4
low density lipoprotein cholesterol measurement
4
75.4
alkaline phosphatase measurement
1
5.7
75.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin domain containing 11
VGNC:5947
453924
Macaque
thioredoxin domain containing 11
711826
Mouse
MGI:1923620
106200
Rat
RGD:1307538
302899
Dog
thioredoxin domain containing 11
VGNC:48010
490003
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin domain containing 11
Macaque
thioredoxin domain containing 11
Mouse
Rat
Dog
thioredoxin domain containing 11
Publication Statistics
PubMed Score 14.97
PubMed score by year
PubTator Score 8.56
PubTator score by year
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Related Publications
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PMID
Year
Title