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Tbio
TRAFD1
TRAF-type zinc finger domain-containing protein 1

Protein Summary
Description
Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity). The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257604
  • ENSP00000257604
  • ENSG00000135148
  • ENST00000412615
  • ENSP00000396526
  • ENST00000552890
  • ENSP00000447340

Symbol
  • FLN29
  • FLN29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
disease perturbation
0.93
kinase perturbation
0.88
transcription factor perturbation
0.84
cell type or tissue
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
NAA15
Tbio
Family:  Enzyme
Novelty:  0.00513055
p_int:  0.9990725
p_ni:  0.0009275
Score:  0.189
Data Source:  BioPlex,STRINGDB
IQCF2
Tdark
Novelty:  12.69230769
p_int:  0.986410808
p_ni:  0.013589192
Data Source:  BioPlex
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.986331651
p_ni:  0.013668349
Data Source:  BioPlex
ASPM
Tbio
Novelty:  0.00599688
p_int:  0.965973478
p_ni:  0.034026522
Score:  0.241
Data Source:  BioPlex,STRINGDB
KDELR1
Tbio
Novelty:  0.0036468
p_int:  0.960967979
p_ni:  0.039032021
Data Source:  BioPlex
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.956226303
p_ni:  0.043773692
p_wrong:  4e-9
Data Source:  BioPlex
XKRX
Tbio
Novelty:  0.35938148
p_int:  0.825154001
p_ni:  0.174845992
p_wrong:  7e-9
Score:  0.251
Data Source:  BioPlex,STRINGDB
ALG10B
Tbio
Family:  Enzyme
Novelty:  0.07131897
p_int:  0.762146405
p_ni:  0.237853594
p_wrong:  1e-9
Score:  0.29
Data Source:  BioPlex,STRINGDB
MAVS
Tbio
Novelty:  0.00241215
Score:  0.904
Data Source:  STRINGDB
TMEM225
Tdark
Novelty:  0.54082299
Score:  0.711
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Regulation of toll-like receptor signaling pathway
WikiPathways
Regulation of toll-like receptor signaling pathway
WikiPathways
TLR4 Signaling and Tolerance
WikiPathways
Toll-like Receptor Signaling
WikiPathways
Fibrin Complement Receptor 3 Signaling Pathway
Name
Explore in Pharos
Explore in Source
Regulation of toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway
TLR4 Signaling and Tolerance
Toll-like Receptor Signaling
Fibrin Complement Receptor 3 Signaling Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (56)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
2
2
98
energy intake
1
2
0
1.7
97.1
high density lipoprotein cholesterol measurement
2
2
2
96.1
blood urea nitrogen measurement
2
2
2
95.1
serum gamma-glutamyl transferase measurement
1
1
1
94.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
98
energy intake
0
1.7
97.1
high density lipoprotein cholesterol measurement
2
96.1
blood urea nitrogen measurement
2
95.1
serum gamma-glutamyl transferase measurement
1
94.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TRAF-type zinc finger domain containing 1
VGNC:10081
452259
Macaque
TRAF-type zinc finger domain containing 1
711635
Mouse
MGI:1923551
231712
Rat
RGD:620171
114635
Dog
TRAF-type zinc finger domain containing 1
VGNC:47771
477484
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TRAF-type zinc finger domain containing 1
Macaque
TRAF-type zinc finger domain containing 1
Mouse
Rat
Dog
TRAF-type zinc finger domain containing 1
Publication Statistics
PubMed Score 9.00
PubMed score by year
PubTator Score 2.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title