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Tdark
TMEM68
Transmembrane protein 68

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334667
  • ENSP00000335416
  • ENSG00000167904
  • ENST00000434581
  • ENSP00000395204
  • ENST00000521229
  • ENSP00000429210
  • ENST00000522576
  • ENSP00000431047
  • ENST00000617782
  • ENSP00000478242
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
disease perturbation
0.68
cell type or tissue
0.67
kinase perturbation
0.66
transcription factor binding site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.999998186
p_ni:  0.000001814
Score:  0.197
Data Source:  BioPlex,STRINGDB
LYPD6
Tbio
Novelty:  0.13867181
p_int:  0.999998058
p_ni:  0.000001942
Score:  0.234
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.999636515
p_ni:  0.000363473
p_wrong:  1.2e-8
Data Source:  BioPlex
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.997007014
p_ni:  0.001991006
p_wrong:  0.00100198
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.994331219
p_ni:  0.005668671
p_wrong:  1.1e-7
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.981203253
p_ni:  0.009410008
p_wrong:  0.009386739
Data Source:  BioPlex
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.960787286
p_ni:  0.031332649
p_wrong:  0.007880065
Score:  0.198
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.955804148
p_ni:  0.0376817
p_wrong:  0.006514152
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.888693047
p_ni:  0.106586883
p_wrong:  0.00472007
Data Source:  BioPlex
SLC6A20
Tbio
Family:  Transporter
Novelty:  0.01435823
p_int:  0.825416585
p_ni:  0.028035535
p_wrong:  0.14654788
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
83.5
monocyte count
1
1
1
21.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
83.5
monocyte count
1
21.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 68
VGNC:780
464181
Macaque
transmembrane protein 68
695447
Mouse
MGI:1919348
72098
Rat
RGD:1309006
312946
Dog
transmembrane protein 68
VGNC:47600
486958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 68
Macaque
transmembrane protein 68
Mouse
Rat
Dog
transmembrane protein 68
Publication Statistics
PubMed Score 2.16
PubMed score by year
PubTator Score 0.20
PubTator score by year
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Related Publications
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PMID
Year
Title