Tdark TMEM31 Transmembrane protein 31

Protein Summary

Uniprot Accession IDs

• Q5JXX7
• Q8NHR4

Gene Name

• TMEM31

Ensembl ID

• ENST00000319560
• ENSP00000316940
• ENSG00000179363

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.48
chemical	0.41
cellular component	0.38
cell line	0.36
virus perturbation	0.28

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.74   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.74   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (61)

Explore Interacting Targets

1 – 10 of 61

• See Interactions on String-DB

VPS13D

Tdark

Novelty:  0.12578583

p_int:  0.999999975

p_ni:  2.5e-8

Data Source:  BioPlex

ZRANB1

Tbio

Family:  Enzyme

Novelty:  0.07721072

p_int:  0.999998043

p_ni:  8.51e-7

p_wrong:  0.000001106

Data Source:  BioPlex

ATXN3

Tbio

Novelty:  0.00201109

p_int:  0.999992214

p_ni:  0.000005918

p_wrong:  0.000001868

Data Source:  BioPlex

CCDC92

Tbio

Novelty:  0.32125749

p_int:  0.999971713

p_ni:  0.000028267

p_wrong:  2.1e-8

Data Source:  BioPlex

UBB

Tbio

Novelty:  0.00661254

p_int:  0.999939253

p_ni:  0.000060565

p_wrong:  1.82e-7

Data Source:  BioPlex

UBQLN1

Tbio

Novelty:  0.00921991

p_int:  0.999936835

p_ni:  0.000063165

Data Source:  BioPlex

USP36

Tbio

Family:  Enzyme

Novelty:  0.02779727

p_int:  0.999934651

p_ni:  0.000064788

p_wrong:  5.6e-7

Data Source:  BioPlex

RAP1A

Tchem

Family:  Enzyme

Novelty:  0.00375413

p_int:  0.999934622

p_ni:  0.000044795

p_wrong:  0.000020583

Data Source:  BioPlex

VPS13C

Tbio

Novelty:  0.05207291

p_int:  0.999862368

p_ni:  0.000137632

Data Source:  BioPlex

UBXN7

Tbio

Novelty:  0.07437638

p_int:  0.999725926

p_ni:  0.000271863

p_wrong:  0.00000221

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

Find Similar Targets

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	1	1		47.7
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		12.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1		47.7
lymphocyte percentage of leukocytes	EFO_0007993	1		12.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Membrane
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
lymphocyte percentage of leukocytes
mean platelet volume

IDG Resources

No IDG generated resources found

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 31	VGNC:11615	100615834
Macaque	transmembrane protein 31		100429773
Dog	transmembrane protein 31 [Source:HGNC Symbol;Acc:HGNC:28601]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 31
Macaque	transmembrane protein 31
Dog	transmembrane protein 31 [Source:HGNC Symbol;Acc:HGNC:28601]

Publication Statistics

PubMed Score 1.74

PubMed score by year

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PubTator Score 1.00

PubTator score by year

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Related Publications

Text Mined References (3)

Items per page:

10

0 of 0

PMID	Year	Title