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Tdark
TMEM25
Transmembrane protein 25

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313236
  • ENSP00000315635
  • ENSG00000149582
  • ENST00000354064
  • ENSP00000278959
  • ENST00000354284
  • ENSP00000346237
  • ENST00000359862
  • ENSP00000352924
  • ENST00000411589
  • ENSP00000411882
  • ENST00000442938
  • ENSP00000416071
  • ENST00000524725
  • ENSP00000431205
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
virus perturbation
0.83
gene perturbation
0.74
kinase perturbation
0.71
microRNA
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
CES3
Tbio
Family:  Enzyme
Novelty:  0.00938734
p_int:  0.99999951
p_ni:  4.3e-7
p_wrong:  6e-8
Score:  0.157
Data Source:  BioPlex,STRINGDB
HTRA3
Tbio
Family:  Enzyme
Novelty:  0.09721543
p_int:  0.999999159
p_ni:  5.19e-7
p_wrong:  3.22e-7
Score:  0.243
Data Source:  BioPlex,STRINGDB
HTRA1
Tchem
Family:  Enzyme
Novelty:  0.0016879
p_int:  0.999947389
p_ni:  0.000052256
p_wrong:  3.56e-7
Data Source:  BioPlex
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
p_int:  0.999568211
p_ni:  0.000431619
p_wrong:  1.7e-7
Data Source:  BioPlex
LARGE1
Tbio
Family:  Enzyme
Novelty:  0.02518701
p_int:  0.999325701
p_ni:  0.000602168
p_wrong:  0.000072131
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.999265912
p_ni:  0.000734088
Data Source:  BioPlex
NID2
Tbio
Novelty:  0.01638372
p_int:  0.998891939
p_ni:  0.001108018
p_wrong:  4.3e-8
Data Source:  BioPlex
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.998688656
p_ni:  0.001311323
p_wrong:  2.1e-8
Data Source:  BioPlex
GALNT18
Tbio
Family:  Enzyme
Novelty:  0.15496205
p_int:  0.998374435
p_ni:  0.001625563
p_wrong:  1e-9
Score:  0.194
Data Source:  BioPlex,STRINGDB
FUZ
Tbio
Novelty:  0.03001976
p_int:  0.997950151
p_ni:  0.001063864
p_wrong:  0.000985984
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.4
94.9
6
2
0
1.3
92.2
alkaline phosphatase measurement
2
2
2
91.6
heel bone mineral density
3
1
4
81.9
1
1
0
1.1
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
94.9
0
1.3
92.2
alkaline phosphatase measurement
2
91.6
heel bone mineral density
4
81.9
0
1.1
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 25
VGNC:970
451588
Macaque
transmembrane protein 25
700466
Mouse
MGI:1918937
71687
Rat
RGD:1596132
689172
Dog
transmembrane protein 25
VGNC:47555
610739
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 25
Macaque
transmembrane protein 25
Mouse
Rat
Dog
transmembrane protein 25
Publication Statistics
PubMed Score 3.98
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
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PMID
Year
Title