Tdark TMEM171 Transmembrane protein 171

Protein Summary

Uniprot Accession IDs

• Q8WVE6
• Q8N0S1
• Q8TDT7

Gene Name

• TMEM171

Ensembl ID

• ENST00000287773
• ENSP00000287773
• ENSG00000157111
• ENST00000454765
• ENSP00000415030

Symbol

• PRP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
tissue sample	0.75
histone modification site profile	0.63
cell type or tissue	0.56
gene perturbation	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.28   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.28   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (94)

Explore Interacting Targets

1 – 10 of 94

• See Interactions on String-DB

CHAMP1

Tbio

Novelty:  0.09520274

p_int:  0.999987565

p_ni:  0.000012435

Score:  0.158

Data Source:  BioPlex,STRINGDB

WWOX

Tbio

Family:  Enzyme

Novelty:  0.00335243

p_int:  0.999971158

p_ni:  0.000028842

Data Source:  BioPlex

MCM10

Tbio

Novelty:  0.0136058

p_int:  0.999912572

p_ni:  0.000087428

Score:  0.257

Data Source:  BioPlex,STRINGDB

NEDD4L

Tbio

Family:  Enzyme

Novelty:  0.00250567

p_int:  0.999756253

p_ni:  0.000243747

Data Source:  BioPlex

TPCN1

Tchem

Family:  IC

Novelty:  0.003844

p_int:  0.999610785

p_ni:  0.000380734

p_wrong:  0.000008481

Score:  0.158

Data Source:  BioPlex,STRINGDB

STXBP4

Tbio

Novelty:  0.08831326

p_int:  0.999389157

p_ni:  0.000610843

Data Source:  BioPlex

GPRC5B

Tbio

Family:  GPCR

Novelty:  0.05128765

p_int:  0.999138203

p_ni:  0.000860406

p_wrong:  0.000001391

Data Source:  BioPlex

HDLBP

Tbio

Novelty:  0.00979636

p_int:  0.999013331

p_ni:  0.000986669

Data Source:  BioPlex

NEDD4

Tchem

Family:  Enzyme

Novelty:  0.00281725

p_int:  0.998764983

p_ni:  0.001235017

Data Source:  BioPlex

SLC25A24

Tbio

Family:  Transporter

Novelty:  0.06151955

p_int:  0.998745381

p_ni:  0.001254619

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

Find Similar Targets

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	5	4	7		96.6
aspartate aminotransferase measurement	EFO_0004736	2	2	1	12.7	83.5
blood urea nitrogen measurement	EFO_0004741	2	2	2		78.3
mean platelet volume	EFO_0004584	1	2	2		68.8
serum urea measurement	EFO_0009795	2	2	2		61.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	7		96.6
aspartate aminotransferase measurement	EFO_0004736	1	12.7	83.5
blood urea nitrogen measurement	EFO_0004741	2		78.3
mean platelet volume	EFO_0004584	2		68.8
serum urea measurement	EFO_0009795	2		61.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
aspartate aminotransferase measurement
blood urea nitrogen measurement
factor VIII measurement
high density lipoprotein cholesterol measurement
lymphocyte count
mean platelet volume
serum non-albumin protein measurement
serum urea measurement
urate measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 171	VGNC:4201	740843
Macaque	transmembrane protein 171		702863
Mouse	transmembrane protein 171	MGI:2685751	380863
Rat	transmembrane protein 171	RGD:1359492	293634
Dog	transmembrane protein 171	VGNC:47497	100855504

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transmembrane protein 171
Macaque	transmembrane protein 171
Mouse	transmembrane protein 171
Rat	transmembrane protein 171
Dog	transmembrane protein 171

Publication Statistics

PubMed Score 0.28

PubMed score by year

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PubTator Score 23.77

PubTator score by year

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Related Publications

Text Mined References (9)

Items per page:

10

0 of 0

PMID	Year	Title