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Tdark
TMEM171
Transmembrane protein 171

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287773
  • ENSP00000287773
  • ENSG00000157111
  • ENST00000454765
  • ENSP00000415030

Symbol
  • PRP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
tissue sample
0.75
histone modification site profile
0.63
cell type or tissue
0.56
gene perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.28   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.28   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
CHAMP1
Tbio
Novelty:  0.09520274
p_int:  0.999987565
p_ni:  0.000012435
Score:  0.158
Data Source:  BioPlex,STRINGDB
WWOX
Tbio
Family:  Enzyme
Novelty:  0.00335243
p_int:  0.999971158
p_ni:  0.000028842
Data Source:  BioPlex
MCM10
Tbio
Novelty:  0.0136058
p_int:  0.999912572
p_ni:  0.000087428
Score:  0.257
Data Source:  BioPlex,STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.999756253
p_ni:  0.000243747
Data Source:  BioPlex
TPCN1
Tchem
Family:  IC
Novelty:  0.003844
p_int:  0.999610785
p_ni:  0.000380734
p_wrong:  0.000008481
Score:  0.158
Data Source:  BioPlex,STRINGDB
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.999389157
p_ni:  0.000610843
Data Source:  BioPlex
GPRC5B
Tbio
Family:  GPCR
Novelty:  0.05128765
p_int:  0.999138203
p_ni:  0.000860406
p_wrong:  0.000001391
Data Source:  BioPlex
HDLBP
Tbio
Novelty:  0.00979636
p_int:  0.999013331
p_ni:  0.000986669
Data Source:  BioPlex
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
p_int:  0.998764983
p_ni:  0.001235017
Data Source:  BioPlex
SLC25A24
Tbio
Family:  Transporter
Novelty:  0.06151955
p_int:  0.998745381
p_ni:  0.001254619
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
4
7
96.6
aspartate aminotransferase measurement
2
2
1
12.7
83.5
blood urea nitrogen measurement
2
2
2
78.3
mean platelet volume
1
2
2
68.8
serum urea measurement
2
2
2
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
7
96.6
aspartate aminotransferase measurement
1
12.7
83.5
blood urea nitrogen measurement
2
78.3
mean platelet volume
2
68.8
serum urea measurement
2
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 171
VGNC:4201
740843
Macaque
transmembrane protein 171
702863
Mouse
MGI:2685751
380863
Rat
RGD:1359492
293634
Dog
transmembrane protein 171
VGNC:47497
100855504
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 171
Macaque
transmembrane protein 171
Mouse
Rat
Dog
transmembrane protein 171
Publication Statistics
PubMed Score 0.28
PubMed score by year
PubTator Score 23.77
PubTator score by year
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Related Publications
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PMID
Year
Title