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Tbio
TFDP3
Transcription factor Dp family member 3

Protein Summary
Description
Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase. This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310125
  • ENSP00000385461
  • ENSG00000183434

Symbol
  • DP4
  • HCA661
  • DP4
  • CT30
  • HCA661
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
protein domain
0.73
microRNA
0.59
gene perturbation
0.58
disease
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 490.67   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 490.67   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
E2F3
Tbio
Family:  TF
Novelty:  0.00287552
p_int:  0.999999277
p_ni:  3e-9
p_wrong:  7.2e-7
Score:  0.872
Data Source:  BioPlex,STRINGDB
E2F4
Tbio
Family:  TF
Novelty:  0.00317412
p_int:  0.999984867
p_ni:  4.11e-7
p_wrong:  0.000014722
Score:  0.949
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.998289311
p_ni:  0.001710688
Score:  0.151
Data Source:  BioPlex,STRINGDB
ERCC6L
Tbio
Novelty:  0.01959203
p_int:  0.990683335
p_ni:  0.009312155
p_wrong:  0.00000451
Score:  0.283
Data Source:  BioPlex,STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
p_int:  0.985648817
p_ni:  0.014351183
Score:  0.221
Data Source:  BioPlex,STRINGDB
DNAJB5
Tbio
Novelty:  0.20703358
p_int:  0.960406377
p_ni:  0.039592506
p_wrong:  0.000001117
Data Source:  BioPlex
ALMS1
Tbio
Novelty:  0.00694228
p_int:  0.9536692
p_ni:  0.0463308
Data Source:  BioPlex
CCDC88A
Tbio
Novelty:  0.01077253
p_int:  0.950993614
p_ni:  0.049005698
p_wrong:  6.88e-7
Data Source:  BioPlex
RB1
Tchem
Novelty:  0.00063798
p_int:  0.939017736
p_ni:  0.060982241
p_wrong:  2.3e-8
Score:  0.872
Data Source:  BioPlex,STRINGDB
ZNHIT2
Tbio
Novelty:  0.13370912
p_int:  0.933540746
p_ni:  0.066442055
p_wrong:  0.000017199
Score:  0.16
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor Dp family member 3
VGNC:2906
473787
Macaque
transcription factor Dp family member 3
706557
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor Dp family member 3
Macaque
transcription factor Dp family member 3
Publication Statistics
PubMed Score 490.67
PubMed score by year
PubTator Score 82.53
PubTator score by year
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Related Publications
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PMID
Year
Title