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Tbio
SNX8
Sorting nexin-8

Protein Summary
Description
May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222990
  • ENSP00000222990
  • ENSG00000106266

Symbol
  • Mvp1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
cell type or tissue
0.79
hub protein
0.71
interacting protein
0.71
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.58   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.58   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
FBXW7
Tbio
Novelty:  0.00180856
p_int:  0.999996649
p_ni:  0.000003287
p_wrong:  6.4e-8
Score:  0.27
Data Source:  BioPlex,STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
p_int:  0.999903182
p_ni:  0.000096818
Score:  0.423
Data Source:  BioPlex,STRINGDB
TMEM47
Tdark
Novelty:  0.1571161
p_int:  0.998855511
p_ni:  0.001144442
p_wrong:  4.7e-8
Data Source:  BioPlex
RUFY1
Tbio
Novelty:  0.16796947
p_int:  0.997741223
p_ni:  0.002258774
p_wrong:  2e-9
Score:  0.233
Data Source:  BioPlex,STRINGDB
AKT3
Tchem
Family:  Kinase
Novelty:  0.00308931
p_int:  0.983559606
p_ni:  0.016440392
p_wrong:  2e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.895752092
p_ni:  0.006991356
p_wrong:  0.097256553
Score:  0.179
Data Source:  BioPlex,STRINGDB
MSH3
Tbio
Novelty:  0.0036266
Score:  0.993
Data Source:  STRINGDB
SNX1
Tbio
Novelty:  0.01267973
Score:  0.853
Data Source:  STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
Score:  0.838
Data Source:  STRINGDB
SNX3
Tbio
Novelty:  0.02703152
Score:  0.803
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
plasminogen activator inhibitor 1 measurement
2
3
0
545
92
self reported educational attainment
2
3
3
91.1
serum albumin measurement
1
2
2
90.3
mathematical ability
2
3
3
85.8
blood protein measurement
1
1
1
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
plasminogen activator inhibitor 1 measurement
0
545
92
self reported educational attainment
3
91.1
serum albumin measurement
2
90.3
mathematical ability
3
85.8
blood protein measurement
1
84.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 8
VGNC:4513
735925
Macaque
sorting nexin 8
698347
Mouse
MGI:2443816
231834
Rat
RGD:1305791
288504
Dog
sorting nexin 8
VGNC:46644
479767
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 8
Macaque
sorting nexin 8
Mouse
Rat
Dog
sorting nexin 8
Publication Statistics
PubMed Score 41.58
PubMed score by year
PubTator Score 11.44
PubTator score by year
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Related Publications
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PMID
Year
Title