Protein Summary
May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.
- ENST00000222990
- ENSP00000222990
- ENSG00000106266
- Mvp1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.8 | ||
cell type or tissue | 0.79 | ||
hub protein | 0.71 | ||
interacting protein | 0.71 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.58 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 238 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.58 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 238 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (62)
FBXW7
Novelty: 0.00180856
p_int: 0.999996649
p_ni: 0.000003287
p_wrong: 6.4e-8
Score: 0.27
Data Source: BioPlex,STRINGDB
POR
Family: Enzyme
Novelty: 0.00145147
p_int: 0.999903182
p_ni: 0.000096818
Score: 0.423
Data Source: BioPlex,STRINGDB
TMEM47
Novelty: 0.1571161
p_int: 0.998855511
p_ni: 0.001144442
p_wrong: 4.7e-8
Data Source: BioPlex
RUFY1
Novelty: 0.16796947
p_int: 0.997741223
p_ni: 0.002258774
p_wrong: 2e-9
Score: 0.233
Data Source: BioPlex,STRINGDB
AKT3
Family: Kinase
Novelty: 0.00308931
p_int: 0.983559606
p_ni: 0.016440392
p_wrong: 2e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
LACC1
Family: Enzyme
Novelty: 0.03928871
p_int: 0.895752092
p_ni: 0.006991356
p_wrong: 0.097256553
Score: 0.179
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
plasminogen activator inhibitor 1 measurement | 2 | 3 | 0 | 545 | 92 | ||||
self reported educational attainment | 2 | 3 | 3 | 91.1 | |||||
serum albumin measurement | 1 | 2 | 2 | 90.3 | |||||
mathematical ability | 2 | 3 | 3 | 85.8 | |||||
blood protein measurement | 1 | 1 | 1 | 84.9 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
plasminogen activator inhibitor 1 measurement | 0 | 545 | 92 | ||||
self reported educational attainment | 3 | 91.1 | |||||
serum albumin measurement | 2 | 90.3 | |||||
mathematical ability | 3 | 85.8 | |||||
blood protein measurement | 1 | 84.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sorting nexin 8 | VGNC:4513 | 735925 | |||||
Macaque | sorting nexin 8 | 698347 | ||||||
Mouse | MGI:2443816 | 231834 | ||||||
Rat | RGD:1305791 | 288504 | ||||||
Dog | sorting nexin 8 | VGNC:46644 | 479767 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sorting nexin 8 | |||||
Macaque | sorting nexin 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sorting nexin 8 | |||||
Publication Statistics
PubMed Score 41.58
PubMed score by year
PubTator Score 11.44
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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