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Tbio
SETDB2
Histone-lysine N-methyltransferase SETDB2

Protein Summary
Description
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [prov ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317257
  • ENSP00000326477
  • ENSG00000136169
  • ENST00000354234
  • ENSP00000346175

Symbol
  • C13orf4
  • CLLD8
  • KMT1F
  • CLLD8
  • CLLL8
  • KMT1F
  • C13orf4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
molecular function
0.81
biological process
0.68
transcription factor
0.66
microRNA
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.32   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.32   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
ARL14EP
Tdark
Novelty:  0.58569411
p_int:  0.99999997
p_ni:  6e-9
p_wrong:  2.4e-8
Score:  0.831
Data Source:  BioPlex,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.999999913
p_ni:  8.6e-8
p_wrong:  1e-9
Data Source:  BioPlex
SENP7
Tchem
Family:  Enzyme
Novelty:  0.00955615
p_int:  0.99999505
p_ni:  4.1e-8
p_wrong:  0.000004909
Score:  0.381
Data Source:  BioPlex,STRINGDB
ZNF445
Tdark
Family:  TF
Novelty:  0.43307505
p_int:  0.999993696
p_ni:  0.000006304
Score:  0.275
Data Source:  BioPlex,STRINGDB
DHX16
Tbio
Family:  Enzyme
Novelty:  0.02678951
p_int:  0.99993934
p_ni:  0.00006066
Score:  0.284
Data Source:  BioPlex,STRINGDB
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.978082761
p_ni:  0.021917237
p_wrong:  2e-9
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.97791941
p_ni:  0.022080579
p_wrong:  1.1e-8
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.957577706
p_ni:  0.041952837
p_wrong:  0.000469457
Data Source:  BioPlex
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.930699899
p_ni:  0.069299918
p_wrong:  1.83e-7
Data Source:  BioPlex
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.918649321
p_ni:  0.081350679
Score:  0.159
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
89.1
myeloid white cell count
2
2
2
88
monocyte count
2
2
2
87.6
leukocyte count
1
1
1
74.8
refractive error measurement
2
2
1
6.3
67.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
89.1
myeloid white cell count
2
88
monocyte count
2
87.6
leukocyte count
1
74.8
refractive error measurement
1
6.3
67.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET domain bifurcated 2
VGNC:7303
452719
Macaque
SET domain bifurcated 2
706277
Mouse
MGI:2685139
239122
Rat
RGD:2319564
100361710
Dog
SET domain bifurcated 2
VGNC:46061
485441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET domain bifurcated 2
Macaque
SET domain bifurcated 2
Mouse
Rat
Dog
SET domain bifurcated 2
Publication Statistics
PubMed Score 22.32
PubMed score by year
PubTator Score 10.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title