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Tbio
SESTD1
SEC14 domain and spectrin repeat-containing protein 1

Protein Summary
Description
May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428443
  • ENSP00000415332
  • ENSG00000187231

Symbol
  • SOLO
  • SOLO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
microRNA
0.85
virus perturbation
0.76
histone modification site profile
0.7
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.82   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.82   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
DACT3
Tbio
Novelty:  0.04684884
p_int:  0.999999989
p_ni:  9e-9
p_wrong:  2e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999998232
p_ni:  0.000001768
Score:  0.209
Data Source:  BioPlex,STRINGDB
SSX2
Tbio
Novelty:  0.00227167
p_int:  0.99999735
p_ni:  0.00000265
Score:  0.161
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999986919
p_ni:  0.000013051
p_wrong:  2.9e-8
Data Source:  BioPlex
IRAK2
Tbio
Family:  Kinase
Novelty:  0.01496024
p_int:  0.99998282
p_ni:  0.00001718
Score:  0.269
Data Source:  BioPlex,STRINGDB
ARL11
Tbio
Family:  Enzyme
Novelty:  0.04033783
p_int:  0.999965134
p_ni:  0.000034866
Score:  0.32
Data Source:  BioPlex,STRINGDB
ZNF669
Tdark
Family:  TF
Novelty:  2.09725685
p_int:  0.999941601
p_ni:  0.000058224
p_wrong:  1.75e-7
Data Source:  BioPlex
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.999891595
p_ni:  0.000108349
p_wrong:  5.6e-8
Data Source:  BioPlex
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999873231
p_ni:  0.00012333
p_wrong:  0.000003439
Data Source:  BioPlex
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.985406929
p_ni:  0.00579981
p_wrong:  0.008793261
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
33.1
1
1
0
3.1
17.8
response to lithium ion
1
1
0
3.1
17.8
intelligence
1
1
1
11.7
1
1
1
11.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
33.1
0
3.1
17.8
response to lithium ion
0
3.1
17.8
intelligence
1
11.7
1
11.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC14 and spectrin domain containing 1
VGNC:2813
470595
Macaque
SEC14 and spectrin domain containing 1
703755
Mouse
MGI:1916262
228071
Rat
RGD:1562244
295678
Dog
SEC14 and spectrin domain containing 1
VGNC:46050
478823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC14 and spectrin domain containing 1
Macaque
SEC14 and spectrin domain containing 1
Mouse
Rat
Dog
SEC14 and spectrin domain containing 1
Publication Statistics
PubMed Score 6.82
PubMed score by year
PubTator Score 7.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title