Tdark RNF166 RING finger protein 166

Protein Summary

Uniprot Accession IDs

• Q96A37
• B3KQ03
• D3DX75
• H3BTU8
• Q96DM0

Gene Name

• RNF166

Ensembl ID

• ENST00000312838
• ENSP00000326095
• ENSG00000158717
• ENST00000537718
• ENSP00000446301
• ENST00000541206
• ENSP00000440454
• ENST00000567844
• ENSP00000457336

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
disease perturbation	0.74
protein domain	0.73
transcription factor binding site profile	0.73
transcription factor	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (49)

Explore Interacting Targets

1 – 10 of 49

• See Interactions on String-DB

LIG1

Tchem

Family:  Enzyme

Novelty:  0.00326816

p_int:  0.999998636

p_ni:  0.000001297

p_wrong:  6.7e-8

Score:  0.34

Data Source:  BioPlex,STRINGDB

TNKS2

Tchem

Family:  Enzyme

Novelty:  0.00938509

p_int:  0.999997572

p_ni:  0.000002428

Data Source:  BioPlex

TNKS

Tchem

Family:  Enzyme

Novelty:  0.00404545

p_int:  0.999990241

p_ni:  0.000009759

Data Source:  BioPlex

TNFAIP6

Tbio

Novelty:  0.0046811

p_int:  0.999921137

p_ni:  0.000039366

p_wrong:  0.000039497

Data Source:  BioPlex

PARP11

Tbio

Family:  Enzyme

Novelty:  0.11901686

p_int:  0.999890182

p_ni:  0.000107041

p_wrong:  0.000002777

Score:  0.787

Data Source:  BioPlex,STRINGDB

MPDZ

Tbio

Novelty:  0.01656439

p_int:  0.999769557

p_ni:  0.000230443

Score:  0.189

Data Source:  BioPlex,STRINGDB

PARP12

Tchem

Family:  Enzyme

Novelty:  0.08076657

p_int:  0.999684542

p_ni:  0.00022912

p_wrong:  0.000086338

Score:  0.538

Data Source:  BioPlex,STRINGDB

NF2

Tbio

Novelty:  0.00055092

p_int:  0.999555445

p_ni:  0.000444555

Score:  0.343

Data Source:  BioPlex,STRINGDB

TNFAIP3

Tbio

Novelty:  0.00257088

p_int:  0.999545963

p_ni:  0.000304585

p_wrong:  0.000149452

Score:  0.173

Data Source:  BioPlex,STRINGDB

KIF1A

Tbio

Novelty:  0.00505209

p_int:  0.999343176

p_ni:  0.000656796

p_wrong:  2.8e-8

Score:  0.173

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Functions (1)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (29)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 29

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	5	9	10		99.3
HbA1c measurement	EFO_0004541	6	10	11		98.8
mean corpuscular hemoglobin concentration	EFO_0004528	7	5	9		98.2
reticulocyte count	EFO_0007986	6	10	18		97.8
hematocrit	EFO_0004348	4	6	7		97.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 29

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	10		99.3
HbA1c measurement	EFO_0004541	11		98.8
mean corpuscular hemoglobin concentration	EFO_0004528	9		98.2
reticulocyte count	EFO_0007986	18		97.8
hematocrit	EFO_0004348	7		97.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Metal-binding
Reference proteome
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
airway imaging measurement
aspartate aminotransferase measurement
bilirubin measurement
BMI-adjusted hip circumference
body height
erythrocyte count
erythrocyte measurement
feeling "fed-up" measurement
HbA1c measurement
heel bone mineral density

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ring finger protein 166	VGNC:5910	468071
Macaque	ring finger protein 166		711056
Mouse	ring finger protein 166	MGI:1915968	68718
Rat	ring finger protein 166	RGD:1302950	365022
Dog	ring finger protein 166	VGNC:45642	608926

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ring finger protein 166
Macaque	ring finger protein 166
Mouse	ring finger protein 166
Rat	ring finger protein 166
Dog	ring finger protein 166

Publication Statistics

PubMed Score 2.57

PubMed score by year

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PubTator Score 0.64

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (2)

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10

0 of 0

PMID	Year	Title