You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
RNF166
RING finger protein 166

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312838
  • ENSP00000326095
  • ENSG00000158717
  • ENST00000537718
  • ENSP00000446301
  • ENST00000541206
  • ENSP00000440454
  • ENST00000567844
  • ENSP00000457336
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
disease perturbation
0.74
protein domain
0.73
transcription factor binding site profile
0.73
transcription factor
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
LIG1
Tchem
Family:  Enzyme
Novelty:  0.00326816
p_int:  0.999998636
p_ni:  0.000001297
p_wrong:  6.7e-8
Score:  0.34
Data Source:  BioPlex,STRINGDB
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.999997572
p_ni:  0.000002428
Data Source:  BioPlex
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
p_int:  0.999990241
p_ni:  0.000009759
Data Source:  BioPlex
TNFAIP6
Tbio
Novelty:  0.0046811
p_int:  0.999921137
p_ni:  0.000039366
p_wrong:  0.000039497
Data Source:  BioPlex
PARP11
Tbio
Family:  Enzyme
Novelty:  0.11901686
p_int:  0.999890182
p_ni:  0.000107041
p_wrong:  0.000002777
Score:  0.787
Data Source:  BioPlex,STRINGDB
MPDZ
Tbio
Novelty:  0.01656439
p_int:  0.999769557
p_ni:  0.000230443
Score:  0.189
Data Source:  BioPlex,STRINGDB
PARP12
Tchem
Family:  Enzyme
Novelty:  0.08076657
p_int:  0.999684542
p_ni:  0.00022912
p_wrong:  0.000086338
Score:  0.538
Data Source:  BioPlex,STRINGDB
NF2
Tbio
Novelty:  0.00055092
p_int:  0.999555445
p_ni:  0.000444555
Score:  0.343
Data Source:  BioPlex,STRINGDB
TNFAIP3
Tbio
Novelty:  0.00257088
p_int:  0.999545963
p_ni:  0.000304585
p_wrong:  0.000149452
Score:  0.173
Data Source:  BioPlex,STRINGDB
KIF1A
Tbio
Novelty:  0.00505209
p_int:  0.999343176
p_ni:  0.000656796
p_wrong:  2.8e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
5
9
10
99.3
HbA1c measurement
6
10
11
98.8
mean corpuscular hemoglobin concentration
7
5
9
98.2
reticulocyte count
6
10
18
97.8
hematocrit
4
6
7
97.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
10
99.3
HbA1c measurement
11
98.8
mean corpuscular hemoglobin concentration
9
98.2
reticulocyte count
18
97.8
hematocrit
7
97.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 166
VGNC:5910
468071
Macaque
ring finger protein 166
711056
Mouse
MGI:1915968
68718
Rat
RGD:1302950
365022
Dog
ring finger protein 166
VGNC:45642
608926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 166
Macaque
ring finger protein 166
Mouse
Rat
Dog
ring finger protein 166
Publication Statistics
PubMed Score 2.57
PubMed score by year
PubTator Score 0.64
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title