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Tbio
RABEP2
Rab GTPase-binding effector protein 2

Protein Summary
Description
Plays a role in membrane trafficking and in homotypic early endosome fusion.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357573
  • ENSP00000350186
  • ENSG00000177548
  • ENST00000358201
  • ENSP00000350934

Symbol
  • RABPT5B
  • FRA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
transcription factor binding site profile
0.8
kinase perturbation
0.6
protein domain
0.58
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.4   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.4   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
RABGEF1
Tbio
Novelty:  0.02830695
p_int:  0.999999998
p_ni:  2e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.999999827
p_ni:  1.73e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
CPNE5
Tbio
Novelty:  0.09416684
p_int:  0.999995409
p_ni:  0.000004591
Score:  0.222
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999978994
p_ni:  0.000021006
Score:  0.2
Data Source:  BioPlex,STRINGDB
FGFR1OP2
Tbio
Novelty:  0.1082136
p_int:  0.999936729
p_ni:  0.000063271
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.99986872
p_ni:  0.00013128
Score:  0.302
Data Source:  BioPlex,STRINGDB
CPNE4
Tbio
Novelty:  0.08077992
p_int:  0.999136981
p_ni:  0.000863019
Data Source:  BioPlex
RABEP1
Tbio
Family:  Enzyme
Novelty:  0.02318446
p_int:  0.992511551
p_ni:  0.007488421
p_wrong:  2.8e-8
Score:  0.435
Data Source:  BioPlex,STRINGDB
DENND6A
Tbio
Novelty:  4.5572617
p_int:  0.98909167
p_ni:  0.010907818
p_wrong:  5.12e-7
Data Source:  BioPlex
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.971946869
p_ni:  0.028053013
p_wrong:  1.18e-7
Score:  0.282
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
8
30
3.6
98.6
intelligence
8
14
6
6.1
94.2
cognitive function measurement
3
3
4
92.2
mathematical ability
3
2
3
91.4
grip strength measurement
2
2
2
88.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
30
3.6
98.6
intelligence
6
6.1
94.2
cognitive function measurement
4
92.2
mathematical ability
3
91.4
grip strength measurement
2
88.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
rabaptin, RAB GTPase binding effector protein 2
VGNC:10337
454359
Macaque
rabaptin, RAB GTPase binding effector protein 2
707953
Mouse
MGI:1917564
70314
Rat
RGD:621416
80754
Dog
rabaptin, RAB GTPase binding effector protein 2
VGNC:45301
489952
Species
Name
OMA
EggNOG
Inparanoid
Chimp
rabaptin, RAB GTPase binding effector protein 2
Macaque
rabaptin, RAB GTPase binding effector protein 2
Mouse
Rat
Dog
rabaptin, RAB GTPase binding effector protein 2
Publication Statistics
PubMed Score 7.40
PubMed score by year
PubTator Score 37.49
PubTator score by year
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Related Publications
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PMID
Year
Title