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Tbio
FBXL4
F-box/LRR-repeat protein 4

Protein Summary
Description
This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229971
  • ENSP00000229971
  • ENSG00000112234
  • ENST00000369244
  • ENSP00000358247

Symbol
  • FBL4
  • FBL5
  • FBL4
  • FBL5
  • MTDPS13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
kinase perturbation
0.81
virus perturbation
0.76
tissue sample
0.6
transcription factor
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.52   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.52   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 4
VGNC:8718
462894
Macaque
F-box and leucine rich repeat protein 4
693683
Mouse
MGI:2140367
269514
Rat
RGD:1305724
313101
Dog
F-box and leucine rich repeat protein 4
VGNC:40760
481932
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 4
Macaque
F-box and leucine rich repeat protein 4
Mouse
Rat
Dog
F-box and leucine rich repeat protein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKA2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (380)
1 – 10 of 380
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999999986
p_ni: 1.2e-8
p_wrong: 2e-9
Score: 0.976
Data Source: BioPlex,STRINGDB
ATG9B
Tbio
p_int: 0.999998152
p_ni: 0.000001841
p_wrong: 8e-9
Data Source: BioPlex
PLCD1
Tchem
Family: Enzyme
Novelty: 0.00742197
p_int: 0.999997624
p_ni: 0.000002375
Data Source: BioPlex
CRYBG1
Tbio
Novelty: 0.05471025
p_int: 0.999997387
p_ni: 0.000002613
Data Source: BioPlex
HEPHL1
Tbio
Novelty: 0.44678065
p_int: 0.999997035
p_ni: 0.000002965
Data Source: BioPlex
LYG2
Tbio
Family: Enzyme
Novelty: 0.12091256
p_int: 0.999981311
p_ni: 0.000018689
Data Source: BioPlex
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.999975733
p_ni: 0.000024267
Data Source: BioPlex
CRAT
Tbio
Family: Enzyme
Novelty: 0.01242609
p_int: 0.999968039
p_ni: 0.000031954
p_wrong: 7e-9
Score: 0.194
Data Source: BioPlex,STRINGDB
S100A3
Tbio
Novelty: 0.03024004
p_int: 0.999967025
p_ni: 0.00003297
p_wrong: 5e-9
Data Source: BioPlex
VSIG8
Tdark
Novelty: 1.16023405
p_int: 0.999951997
p_ni: 0.000047989
p_wrong: 1.4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  24.52

PubMed score by year
PubTator Score  11.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer