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Tdark
NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Protein Summary
Description
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272907
  • ENSP00000272907
  • ENSG00000144460
  • ENST00000636099
  • ENSP00000490942

Symbol
  • KIAA1486
  • KIAA1486
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.73
cell type or tissue
0.7
cell line
0.55
disease
0.54
cellular component
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
93.1
neuroticism measurement
3
2
1
5.6
88.4
self reported educational attainment
1
1
1
83.6
wellbeing measurement
3
1
3
82.7
cognitive function measurement
1
1
1
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
93.1
neuroticism measurement
1
5.6
88.4
self reported educational attainment
1
83.6
wellbeing measurement
3
82.7
cognitive function measurement
1
75.7
Protein-Protein Interactions (49)
1 – 10 of 49
MORN4
Tdark
Novelty: 0.22826325
p_int: 0.999999995
p_ni: 3e-9
p_wrong: 2e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
HDAC6
Tclin
Family: Epigenetic
Novelty: 0.00122232
p_int: 0.998392308
p_ni: 0.001606304
p_wrong: 0.000001388
Data Source: BioPlex
SEMG1
Tbio
Novelty: 0.0161449
p_int: 0.985161319
p_ni: 0.014738884
p_wrong: 0.000099797
Data Source: BioPlex
SUFU
Tbio
Novelty: 0.00475249
p_int: 0.891079057
p_ni: 0.108920924
p_wrong: 1.9e-8
Data Source: BioPlex
RNF214
Tdark
Novelty: 2.76722057
Score: 0.802
Data Source: STRINGDB
ANKRD10
Tdark
Novelty: 0.6861542
Score: 0.767
Data Source: STRINGDB
ANKRD46
Tbio
Novelty: 0.06546845
Score: 0.75
Data Source: STRINGDB
FBXO24
Tdark
Novelty: 0.70806401
Score: 0.739
Data Source: STRINGDB
CPEB4
Tbio
Novelty: 0.02620557
Score: 0.721
Data Source: STRINGDB
CARS
Tbio
Family: Enzyme
Novelty: 0.02078279
Score: 0.72
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.66

PubMed score by year
PubTator Score  0.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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