Tdark GOLGA6A Golgin subfamily A member 6A

Protein Summary

Description

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encoded by this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underlie genomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority of the related copies of this gene are thought to be transcribed pseudogenes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NYA3
• A8K959
• Q9NYA7

Gene Name

• GOLGA6A

Ensembl ID

• ENST00000290438
• ENSP00000290438
• ENSG00000159289

Symbol

• GLP
• GOLGA6
• GLP
• GOLGA6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.62
cell type or tissue	0.6
tissue sample	0.57
microRNA	0.56
virus perturbation	0.41

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Golgin Subfamily A Member 6a

DTO Classes

Protein / Transporter / Golgin Subfamily A Member 6a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.76   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0