Tbio MS4A12 Membrane-spanning 4-domains subfamily A member 12

Protein Summary

Description

May be involved in signal transduction as a component of a multimeric receptor complex. The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Uniprot Accession IDs

• Q9NXJ0
• F5GX98
• Q8N6L4

Gene Name

• MS4A12

Ensembl ID

• ENST00000016913
• ENSP00000016913
• ENSG00000071203
• ENST00000537076
• ENSP00000440424

Symbol

• Ms4a10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
cell type or tissue	0.63
microRNA	0.57
cell line	0.54
tissue sample	0.36

Protein Classes

PANTHER Classes

Protein / Receptor / Membrane-spanning 4-domains Subfamily A Member 12

DTO Classes

Protein / Receptor / Membrane-spanning 4-domains Subfamily A Member 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0