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Tbio
ZFP57
Zinc finger protein 57 homolog

Protein Summary
Description
Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity). Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376881
  • ENSP00000366078
  • ENSG00000204644
  • ENST00000376883
  • ENSP00000366080
  • ENST00000383628
  • ENSP00000373124
  • ENSG00000206510
  • ENST00000416974
  • ENSP00000396462
  • ENSG00000223858
  • ENST00000435906
  • ENSP00000412932
  • ENSG00000226858
  • ENST00000437216
  • ENSP00000398086
  • ENSG00000223852
  • ENST00000446005
  • ENSP00000394222
  • ENSG00000234669
  • ENST00000448114
  • ENSP00000409118
  • ENSG00000232099
  • ENST00000488757
  • ENSP00000418259
  • ENST00000547542
  • ENSP00000447492
  • ENST00000547911
  • ENSP00000449556
  • ENST00000548001
  • ENSP00000446541
  • ENST00000548337
  • ENSP00000449407
  • ENST00000548574
  • ENSP00000446798
  • ENST00000548769
  • ENSP00000448351
  • ENST00000549167
  • ENSP00000449230
  • ENST00000549501
  • ENSP00000447698
  • ENST00000552809
  • ENSP00000450279
  • ENST00000552898
  • ENSP00000450397
  • ENST00000552987
  • ENSP00000448634
  • ENST00000553137
  • ENSP00000447495

Symbol
  • C6orf40
  • ZNF698
  • TNDM1
  • ZNF698
  • C6orf40
  • bA145L22
  • bA145L22.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.62
PubMedID
0.6
tissue
0.6
protein domain
0.58
transcription factor
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.57   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.57   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (228)
Items per page:
1 – 5 of 228
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
6
2
1.1
87.7
5
6
2
1.1
87.7
5
6
2
1.1
87.7
5
6
2
1.1
87.7
5
6
2
1.1
87.7
Items per page:
1 – 5 of 228
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
87.7
2
1.1
87.7
2
1.1
87.7
2
1.1
87.7
2
1.1
87.7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NU63-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (52)
1 – 10 of 52
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
Score:  0.784
Data Source:  STRINGDB
MOG
Tbio
Novelty:  0.00048664
Score:  0.741
Data Source:  STRINGDB
DNMT3A
Tclin
Family:  Epigenetic
Novelty:  0.00085974
Score:  0.665
Data Source:  STRINGDB
DPPA3
Tbio
Novelty:  0.03361743
Score:  0.655
Data Source:  STRINGDB
DNMT1
Tclin
Family:  Enzyme
Novelty:  0.00042336
Score:  0.652
Data Source:  STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.64
Data Source:  STRINGDB
TSPAN32
Tbio
Novelty:  0.08323845
Score:  0.638
Data Source:  STRINGDB
SNRPN
Tbio
Novelty:  0.002157
Score:  0.629
Data Source:  STRINGDB
DNMT3B
Tchem
Family:  Epigenetic
Novelty:  0.00118766
Score:  0.604
Data Source:  STRINGDB
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
Score:  0.603
Data Source:  STRINGDB
Publication Statistics
PubMed Score  57.57

PubMed score by year
PubTator Score  30.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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