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Tdark
INKA2
PAK4-inhibitor INKA2

Protein Summary
Description
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357260
  • ENSP00000349805
  • ENSG00000197852

Symbol
  • C1orf183
  • FAM212B
  • FAM212B
  • C1orf183
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.8
transcription factor
0.72
cell type or tissue
0.63
small molecule perturbation
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (14)
1 – 10 of 14
CEP128
Tdark
Novelty: 0.37088466
p_int: 0.999988334
p_ni: 0.000003978
p_wrong: 0.000007688
Score: 0.54
Data Source: BioPlex,STRINGDB
CDC42BPB
Tbio
Family: Kinase
Novelty: 0.23112171
p_int: 0.999857487
p_ni: 0.000142513
Score: 0.309
Data Source: BioPlex,STRINGDB
DNASE1L2
Tbio
Family: Enzyme
Novelty: 0.02115905
p_int: 0.99985646
p_ni: 0.000143533
p_wrong: 7e-9
Score: 0.211
Data Source: BioPlex,STRINGDB
CDC42BPA
Tchem
Family: Kinase
Novelty: 0.0422899
p_int: 0.999691477
p_ni: 0.000308523
Score: 0.309
Data Source: BioPlex,STRINGDB
TMEM169
Tdark
Score: 0.733
Data Source: STRINGDB
CTPS1
Tbio
Family: Enzyme
Novelty: 0.00445558
Score: 0.645
Data Source: STRINGDB
CTPS2
Tbio
Family: Enzyme
Novelty: 0.07546492
Score: 0.626
Data Source: STRINGDB
RSRP1
Tdark
Novelty: 1.02857143
Score: 0.593
Data Source: STRINGDB
UBALD2
Tdark
Novelty: 5
Score: 0.553
Data Source: STRINGDB
C2orf80
Tdark
Novelty: 1.51898734
Score: 0.55
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.23

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer