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Tdark
INKA2
PAK4-inhibitor INKA2

Protein Summary
Description
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357260
  • ENSP00000349805
  • ENSG00000197852

Symbol
  • C1orf183
  • FAM212B
  • FAM212B
  • C1orf183
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.8
transcription factor
0.72
cell type or tissue
0.63
small molecule perturbation
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (14)
CEP128
Tbio
Novelty:  0.15843064
p_int:  0.999988334
p_ni:  0.000003978
p_wrong:  0.000007688
Score:  0.54
Data Source:  BioPlex,STRINGDB
CDC42BPB
Tchem
Family:  Kinase
Novelty:  0.12012285
p_int:  0.999857487
p_ni:  0.000142513
Score:  0.309
Data Source:  BioPlex,STRINGDB
DNASE1L2
Tbio
Family:  Enzyme
Novelty:  0.0152658
p_int:  0.99985646
p_ni:  0.000143533
p_wrong:  7e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
CDC42BPA
Tchem
Family:  Kinase
Novelty:  0.02575412
p_int:  0.999691477
p_ni:  0.000308523
Score:  0.309
Data Source:  BioPlex,STRINGDB
TMEM169
Tdark
Novelty:  5.1578082
Score:  0.733
Data Source:  STRINGDB
CTPS1
Tbio
Family:  Enzyme
Novelty:  0.00911596
Score:  0.645
Data Source:  STRINGDB
CTPS2
Tbio
Family:  Enzyme
Novelty:  0.06147923
Score:  0.626
Data Source:  STRINGDB
RSRP1
Tdark
Novelty:  0.74980508
Score:  0.593
Data Source:  STRINGDB
UBALD2
Tdark
Novelty:  2.21418301
Score:  0.553
Data Source:  STRINGDB
C2orf80
Tdark
Novelty:  1.08283503
Score:  0.55
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
84.6
electrocardiography
1
2
52
81.2
self reported educational attainment
2
3
3
70.9
waist-hip ratio
2
2
2
70.4
2
1
0
1.1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
84.6
electrocardiography
52
81.2
self reported educational attainment
3
70.9
waist-hip ratio
2
70.4
0
1.1
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inka box actin regulator 2
VGNC:10627
469407
Mouse
MGI:1923497
109050
Rat
RGD:1306526
310764
Horse
inka box actin regulator 2
VGNC:49409
100063508
Cow
inka box actin regulator 2
VGNC:50127
616754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inka box actin regulator 2
Mouse
Rat
Horse
inka box actin regulator 2
Cow
inka box actin regulator 2
Publication Statistics
PubMed Score 2.87
PubMed score by year
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Related Publications
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PMID
Year
Title