Protein Summary
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
- ENST00000357260
- ENSP00000349805
- ENSG00000197852
- C1orf183
- FAM212B
- FAM212B
- C1orf183
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.87 | ||
transcription factor binding site profile | 0.8 | ||
transcription factor | 0.72 | ||
cell type or tissue | 0.63 | ||
small molecule perturbation | 0.63 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.23 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 114 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.23 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 114 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Gene Ontology Terms (3)
Functions (2)
Components (1)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Protein-Protein Interactions (14)
1 – 10 of 14
CEP128
Novelty: 0.37088466
p_int: 0.999988334
p_ni: 0.000003978
p_wrong: 0.000007688
Score: 0.54
Data Source: BioPlex,STRINGDB
CDC42BPB
Family: Kinase
Novelty: 0.23112171
p_int: 0.999857487
p_ni: 0.000142513
Score: 0.309
Data Source: BioPlex,STRINGDB
DNASE1L2
Family: Enzyme
Novelty: 0.02115905
p_int: 0.99985646
p_ni: 0.000143533
p_wrong: 7e-9
Score: 0.211
Data Source: BioPlex,STRINGDB
CDC42BPA
Family: Kinase
Novelty: 0.0422899
p_int: 0.999691477
p_ni: 0.000308523
Score: 0.309
Data Source: BioPlex,STRINGDB
TMEM169
Score: 0.733
Data Source: STRINGDB
CTPS1
Family: Enzyme
Novelty: 0.00445558
Score: 0.645
Data Source: STRINGDB
CTPS2
Family: Enzyme
Novelty: 0.07546492
Score: 0.626
Data Source: STRINGDB
RSRP1
Novelty: 1.02857143
Score: 0.593
Data Source: STRINGDB
UBALD2
Novelty: 5
Score: 0.553
Data Source: STRINGDB
C2orf80
Novelty: 1.51898734
Score: 0.55
Data Source: STRINGDB
Publication Statistics
PubMed Score 1.23
PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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GWAS Trait