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Tbio
CYTL1
Cytokine-like protein 1

Protein Summary
Description
C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000 [PubMed 10857752]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307746
  • ENSP00000303550
  • ENSG00000170891

Symbol
  • C4orf4
  • C17
  • C4orf4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
gene perturbation
0.76
biological process
0.67
small molecule perturbation
0.63
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.04   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.04   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
72.4
body height
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
72.4
body height
1
6.3
Pathways (7)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
TYROBP Causal Network
WikiPathways
TYROBP Causal Network
WikiPathways
Selenium Metabolism and Selenoproteins
WikiPathways
Folate Metabolism
WikiPathways
Association Between Physico-Chemical Features and Toxicity Associated Pathways
Name
Explore in Pharos
Explore in Source
TYROBP Causal Network
TYROBP Causal Network
Selenium Metabolism and Selenoproteins
Folate Metabolism
Association Between Physico-Chemical Features and Toxicity Associated Pathways
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (28)
1 – 10 of 28
PLAC8
Tbio
Novelty: 0.00882894
Score: 0.736
Data Source: STRINGDB
C12orf57
Tbio
Novelty: 0.00353824
Score: 0.734
Data Source: STRINGDB
BBS9
Tbio
Novelty: 0.01879869
Score: 0.67
Data Source: STRINGDB
SUPT20H
Tbio
Novelty: 0.00625899
Score: 0.669
Data Source: STRINGDB
POR
Tbio
Family: Enzyme
Novelty: 0.00145147
Score: 0.658
Data Source: STRINGDB
HSD3B1
Tchem
Family: Enzyme
Novelty: 0.0019271
Score: 0.561
Data Source: STRINGDB
TBL1XR1
Tbio
Novelty: 0.00503043
Score: 0.558
Data Source: STRINGDB
CYP17A1
Tclin
Family: Enzyme
Novelty: 0.00065091
Score: 0.555
Data Source: STRINGDB
SULT2B1
Tbio
Family: Enzyme
Novelty: 0.02652128
Score: 0.553
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.534
Data Source: STRINGDB
Publication Statistics
PubMed Score  121.04

PubMed score by year
PubTator Score  483.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer