SPAG4
Sperm-associated antigen 4 protein
Protein Summary
Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, ...more
- ENST00000374273
- ENSP00000363391
- ENSG00000061656
- SUN4
- SUN4
- CT127
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.7 | ||
transcription factor binding site profile | 0.7 | ||
gene perturbation | 0.66 | ||
small molecule perturbation | 0.66 | ||
cellular component | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.68 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 80 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.68 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 80 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (47)
CHRNB4
Family: IC
Novelty: 0.01151716
p_int: 0.996395071
p_ni: 1e-9
p_wrong: 0.003604928
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (7)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 3 | 7 | 97.7 | |||||
BMI-adjusted hip circumference | 2 | 16 | 19 | 95.9 | |||||
total cholesterol measurement | 6 | 7 | 12 | 90.3 | |||||
suntan | 1 | 1 | 1 | 87.9 | |||||
low density lipoprotein cholesterol measurement | 3 | 3 | 3 | 82.3 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 7 | 97.7 | |||||
BMI-adjusted hip circumference | 19 | 95.9 | |||||
total cholesterol measurement | 12 | 90.3 | |||||
suntan | 1 | 87.9 | |||||
low density lipoprotein cholesterol measurement | 3 | 82.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sperm associated antigen 4 | VGNC:6270 | 107966383 | |||||
Macaque | sperm associated antigen 4 | 704522 | ||||||
Mouse | MGI:2444120 | 245865 | ||||||
Rat | RGD:620151 | 83623 | ||||||
Dog | sperm associated antigen 4 | VGNC:54733 | 485854 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | sperm associated antigen 4 | |||||
Macaque | sperm associated antigen 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | sperm associated antigen 4 | |||||
Publication Statistics
PubMed Score 26.68
PubMed score by year
PubTator Score 19.02
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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