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Tbio
SPAG4
Sperm-associated antigen 4 protein

Protein Summary
Description
Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374273
  • ENSP00000363391
  • ENSG00000061656

Symbol
  • SUN4
  • SUN4
  • CT127
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
transcription factor binding site profile
0.7
gene perturbation
0.66
small molecule perturbation
0.66
cellular component
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.68   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.68   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.996395071
p_ni:  1e-9
p_wrong:  0.003604928
Data Source:  BioPlex
ODF1
Tbio
Novelty:  0.01272872
Score:  0.953
Data Source:  STRINGDB
SEPT12
Tbio
Novelty:  0.06228277
Score:  0.851
Data Source:  STRINGDB
GABRB1
Tclin
Family:  IC
Novelty:  0.02895574
Score:  0.681
Data Source:  STRINGDB
CATSPER4
Tchem
Family:  IC
Novelty:  0.4554917
Score:  0.674
Data Source:  STRINGDB
SYNE3
Tbio
Novelty:  0.06515065
Score:  0.641
Data Source:  STRINGDB
MRPS18A
Tdark
Novelty:  0.26321707
Score:  0.636
Data Source:  STRINGDB
SPARC
Tbio
Novelty:  0.00063267
Score:  0.633
Data Source:  STRINGDB
ANKRD37
Tdark
Novelty:  0.20756658
Score:  0.607
Data Source:  STRINGDB
STK38L
Tchem
Family:  Kinase
Novelty:  0.05193219
Score:  0.597
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
7
97.7
BMI-adjusted hip circumference
2
16
19
95.9
total cholesterol measurement
6
7
12
90.3
suntan
1
1
1
87.9
low density lipoprotein cholesterol measurement
3
3
3
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
97.7
BMI-adjusted hip circumference
19
95.9
total cholesterol measurement
12
90.3
suntan
1
87.9
low density lipoprotein cholesterol measurement
3
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sperm associated antigen 4
VGNC:6270
107966383
Macaque
sperm associated antigen 4
704522
Mouse
MGI:2444120
245865
Rat
RGD:620151
83623
Dog
sperm associated antigen 4
VGNC:54733
485854
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sperm associated antigen 4
Macaque
sperm associated antigen 4
Mouse
Rat
Dog
sperm associated antigen 4
Publication Statistics
PubMed Score 26.68
PubMed score by year
PubTator Score 19.02
PubTator score by year
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Related Publications
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PMID
Year
Title