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Tbio
MYOZ2
Myozenin-2

Protein Summary
Description
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307128
  • ENSP00000306997
  • ENSG00000172399

Symbol
  • C4orf5
  • CS-1
  • CMH16
  • C4orf5
  • FATZ-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
microRNA
0.67
tissue sample
0.57
gene perturbation
0.53
disease
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.92   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.92   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
95.4
reticulocyte measurement
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
95.4
reticulocyte measurement
1
17.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myozenin 2
VGNC:643
740177
Macaque
myozenin 2
705000
Mouse
MGI:1913063
59006
Rat
RGD:1307669
295426
Dog
myozenin 2
VGNC:43584
478524
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myozenin 2
Macaque
myozenin 2
Mouse
Rat
Dog
myozenin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NPC6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (91)
1 – 10 of 91
LDB3
Tbio
Novelty: 0.01178009
Score: 0.963
Data Source: STRINGDB
TCAP
Tbio
Novelty: 0.00623581
Score: 0.907
Data Source: STRINGDB
TTN
Tbio
Family: Kinase
Novelty: 0.00040356
Score: 0.879
Data Source: STRINGDB
CSRP3
Tbio
Novelty: 0.00892632
Score: 0.863
Data Source: STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.855
Data Source: STRINGDB
LMOD2
Tbio
Novelty: 0.05161048
Score: 0.826
Data Source: STRINGDB
MYOM2
Tbio
Novelty: 0.00032062
Score: 0.821
Data Source: STRINGDB
MYBPC3
Tbio
Novelty: 0.00297478
Score: 0.814
Data Source: STRINGDB
ACTN1
Tbio
Novelty: 0.00654004
Score: 0.808
Data Source: STRINGDB
CAV3
Tbio
Novelty: 0.00190092
Score: 0.805
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.92

PubMed score by year
PubTator Score  37.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer