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Tbio
PSTPIP2
Proline-serine-threonine phosphatase-interacting protein 2

Protein Summary
Description
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409746
  • ENSP00000387261
  • ENSG00000152229
  • ENST00000589328
  • ENSP00000468622

Symbol
  • MAYP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
interacting protein
0.81
histone modification site profile
0.76
tissue sample
0.67
gene perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
PTPN12
Tchem
Family:  Enzyme
Novelty:  0.01333491
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.952
Data Source:  BioPlex,STRINGDB
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999999707
p_ni:  2.61e-7
p_wrong:  3.2e-8
Score:  0.844
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999666719
p_ni:  0.000329876
p_wrong:  0.000003405
Score:  0.514
Data Source:  BioPlex,STRINGDB
PIGN
Tbio
Family:  Enzyme
Novelty:  0.02210783
Score:  0.906
Data Source:  STRINGDB
TNFRSF11A
Tbio
Novelty:  0.0056219
Score:  0.715
Data Source:  STRINGDB
NOSTRIN
Tbio
Novelty:  0.05720571
Score:  0.707
Data Source:  STRINGDB
PTPN18
Tbio
Family:  Enzyme
Novelty:  0.0950339
Score:  0.671
Data Source:  STRINGDB
SRGAP1
Tbio
Family:  Enzyme
Novelty:  0.07072132
Score:  0.663
Data Source:  STRINGDB
FNBP1
Tbio
Novelty:  0.03879767
Score:  0.657
Data Source:  STRINGDB
LPIN2
Tbio
Family:  Enzyme
Novelty:  0.01901948
Score:  0.653
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
11.2
platelet count
1
1
1
9.9
platelet crit
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
11.2
platelet count
1
9.9
platelet crit
1
6.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proline-serine-threonine phosphatase interacting protein 2
VGNC:10008
737635
Macaque
proline-serine-threonine phosphatase interacting protein 2
701032
Mouse
MGI:1335088
19201
Rat
RGD:1563090
307248
Dog
proline-serine-threonine phosphatase interacting protein 2
VGNC:45128
480150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proline-serine-threonine phosphatase interacting protein 2
Macaque
proline-serine-threonine phosphatase interacting protein 2
Mouse
Rat
Dog
proline-serine-threonine phosphatase interacting protein 2
Publication Statistics
PubMed Score 23.82
PubMed score by year
PubTator Score 7.26
PubTator score by year
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Related Publications
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PMID
Year
Title