PSTPIP2
Proline-serine-threonine phosphatase-interacting protein 2
Protein Summary
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
- ENST00000409746
- ENSP00000387261
- ENSG00000152229
- ENST00000589328
- ENSP00000468622
- MAYP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.98 | ||
interacting protein | 0.81 | ||
histone modification site profile | 0.76 | ||
tissue sample | 0.67 | ||
gene perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.82 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 80 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.82 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 80 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (64)
PTPN12
Family: Enzyme
Novelty: 0.01333491
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.952
Data Source: BioPlex,STRINGDB
LPXN
Novelty: 0.00796678
p_int: 0.999999707
p_ni: 2.61e-7
p_wrong: 3.2e-8
Score: 0.844
Data Source: BioPlex,STRINGDB
VAPA
Novelty: 0.00169209
p_int: 0.999666719
p_ni: 0.000329876
p_wrong: 0.000003405
Score: 0.514
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 11.2 | |||||
platelet count | 1 | 1 | 1 | 9.9 | |||||
platelet crit | 1 | 1 | 1 | 6.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 11.2 | |||||
platelet count | 1 | 9.9 | |||||
platelet crit | 1 | 6.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | proline-serine-threonine phosphatase interacting protein 2 | VGNC:10008 | 737635 | |||||
Macaque | proline-serine-threonine phosphatase interacting protein 2 | 701032 | ||||||
Mouse | MGI:1335088 | 19201 | ||||||
Rat | RGD:1563090 | 307248 | ||||||
Dog | proline-serine-threonine phosphatase interacting protein 2 | VGNC:45128 | 480150 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | proline-serine-threonine phosphatase interacting protein 2 | |||||
Macaque | proline-serine-threonine phosphatase interacting protein 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | proline-serine-threonine phosphatase interacting protein 2 | |||||
Publication Statistics
PubMed Score 23.82
PubMed score by year
PubTator Score 7.26
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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