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Tbio
TMEM38A
Trimeric intracellular cation channel type A

Protein Classes
Protein Summary
Description
Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000187762
  • ENSP00000187762
  • ENSG00000072954

Symbol
  • TRICA
  • TRIC-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.77
transcription factor binding site profile
0.65
transcription factor
0.62
molecular function
0.6
tissue
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
1
2
21.5
intelligence
1
1
1
21.5
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
21.5
intelligence
1
21.5
1
21.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 38A
VGNC:2221
455817
Mouse
MGI:1921416
74166
Rat
RGD:1307901
306327
Dog
transmembrane protein 38A
VGNC:47574
610207
Horse
transmembrane protein 38A
VGNC:24288
100069904
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 38A
Mouse
Rat
Dog
transmembrane protein 38A
Horse
transmembrane protein 38A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H6F2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (76)
1 – 10 of 76
HSD3B2
Tclin
Family:  Enzyme
Novelty:  0.00711552
p_int:  0.999999982
p_wrong:  1.7e-8
Data Source:  BioPlex
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.987383177
p_ni:  0.000945137
p_wrong:  0.011671686
Data Source:  BioPlex
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.985533684
p_ni:  0.005648281
p_wrong:  0.008818036
Score:  0.261
Data Source:  BioPlex,STRINGDB
PCP2
Tdark
Novelty:  0.05083955
p_int:  0.97516191
p_ni:  0.004600961
p_wrong:  0.020237129
Score:  0.513
Data Source:  BioPlex,STRINGDB
DOK2
Tbio
Novelty:  0.02651438
p_int:  0.967830553
p_ni:  0.026011133
p_wrong:  0.006158314
Score:  0.295
Data Source:  BioPlex,STRINGDB
LZTFL1
Tbio
Novelty:  0.10578428
p_int:  0.813062704
p_ni:  0.186937296
Score:  0.239
Data Source:  BioPlex,STRINGDB
SRL
Tdark
Novelty:  0.03172682
Score:  0.835
Data Source:  STRINGDB
PDLIM7
Tbio
Novelty:  0.00544518
Score:  0.834
Data Source:  STRINGDB
MYL1
Tbio
Novelty:  0.00360262
Score:  0.833
Data Source:  STRINGDB
TMEM70
Tbio
Novelty:  0.03111438
Score:  0.807
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.40

PubMed score by year
PubTator Score  7.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer