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Tbio
NXF5
Nuclear RNA export factor 5

Protein Summary
Description
Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons. This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and is implicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in other family members that are required for export activity, and may be an evolving pseudogene. Alternatively spliced transcript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263032
  • ENSP00000263032
  • ENSG00000126952
  • ENST00000332614
  • ENSP00000331535
  • ENST00000361330
  • ENSP00000354539
  • ENST00000372803
  • ENSP00000361889
  • ENST00000473265
  • ENSP00000426978
  • ENST00000493509
  • ENSP00000422976
  • ENST00000537026
  • ENSP00000442401

Symbol
  • TAPL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.63
tissue
0.44
disease
0.43
cell line
0.42


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
69.5
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear RNA export factor 5
VGNC:1350
100610724
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear RNA export factor 5
Pathways (5)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Ribosome biogenesis in eukaryotes
KEGG
mRNA surveillance pathway
KEGG
RNA transport
KEGG
Influenza A
KEGG
Herpes simplex virus 1 infection
Name
Explore in Pharos
Explore in Source
Ribosome biogenesis in eukaryotes
mRNA surveillance pathway
RNA transport
Influenza A
Herpes simplex virus 1 infection
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (125)
1 – 10 of 125
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.979114311
p_ni: 0.020885689
Data Source: BioPlex
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.832136762
p_ni: 0.167863238
Score: 0.237
Data Source: BioPlex,STRINGDB
NXT1
Tbio
Novelty: 0.02307435
Score: 0.992
Data Source: STRINGDB
NXT2
Tdark
Novelty: 0.03767394
Score: 0.983
Data Source: STRINGDB
RAE1
Tbio
Novelty: 0.01342883
Score: 0.971
Data Source: STRINGDB
NUP98
Tbio
Family: Enzyme
Novelty: 0.00401452
Score: 0.952
Data Source: STRINGDB
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
Score: 0.903
Data Source: STRINGDB
ALYREF
Tbio
Novelty: 0.00523802
Score: 0.898
Data Source: STRINGDB
THOC5
Tbio
Novelty: 0.04618391
Score: 0.886
Data Source: STRINGDB
NUTF2
Tbio
Novelty: 0.00334688
Score: 0.878
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.04

PubMed score by year
PubTator Score  4.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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