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Tbio
IMUP
Immortalization up-regulated protein

Protein Summary
Description
The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301246
  • ENSP00000301246
  • ENSG00000167644
  • ENST00000588605
  • ENSP00000464940

Symbol
  • C19orf33
  • IMUP
  • H2RSP
  • IMUP-1
  • IMUP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.74   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.74   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
23.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
23.4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZP8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (9)
1 – 9 of 9
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
Score: 0.759
Data Source: STRINGDB
PPP1R14A
Tbio
Family: Enzyme
Novelty: 0.00231198
Score: 0.757
Data Source: STRINGDB
C4orf19
Tdark
Novelty: 2.1863624
Score: 0.53
Data Source: STRINGDB
CDIPT
Tbio
Family: Enzyme
Novelty: 0.00560887
Score: 0.483
Data Source: STRINGDB
TTMP
Tdark
Novelty: 0.22491726
Score: 0.447
Data Source: STRINGDB
C11orf1
Tdark
Novelty: 1.59731466
Score: 0.429
Data Source: STRINGDB
SAMD14
Tbio
Novelty: 0.19225592
Score: 0.422
Data Source: STRINGDB
SMIM14
Tdark
Novelty: 1.61368686
Score: 0.418
Data Source: STRINGDB
PPP1R12A
Tbio
Family: Enzyme
Novelty: 0.0028297
Score: 0.412
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.74

PubMed score by year
PubTator Score  7.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer