Tbio PKIB cAMP-dependent protein kinase inhibitor beta

Protein Summary

Description

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q9C010
• B2RCK2
• Q567T9
• Q5T0Z7
• PKI-beta

Gene Name

• PKIB

Ensembl ID

• ENST00000258014
• ENSP00000258014
• ENSG00000135549
• ENST00000354275
• ENSP00000346227
• ENST00000368448
• ENSP00000357433
• ENST00000368452
• ENSP00000357437
• ENST00000392490
• ENSP00000376280
• ENST00000392491
• ENSP00000376281
• ENST00000615438
• ENSP00000480824

Symbol

• PRKACN2
• PRKACN2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
PubMedID	0.8
transcription factor	0.77
transcription factor binding site profile	0.72
histone modification site profile	0.67

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Camp-dependent Protein Kinase Inhibitor Beta

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Camp-dependent Protein Kinase Inhibitor Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.66   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.66   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0