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Tbio
APOO
MICOS complex subunit MIC26

Protein Summary
Description
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892). This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379226
  • ENSP00000368528
  • ENSG00000184831

Symbol
  • FAM121B
  • MIC23
  • MIC26
  • MIC26
  • Mic23
  • My025
  • FAM121B
  • MICOS26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor perturbation
0.68
transcription factor binding site profile
0.66
cell type or tissue
0.59
tissue sample
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.27   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.27   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein O
VGNC:1431
465539
Macaque
apolipoprotein O
698137
Mouse
MGI:1915566
68316
Rat
RGD:1565289
363474
Horse
apolipoprotein O
VGNC:15425
100060141
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein O
Macaque
apolipoprotein O
Mouse
Rat
Horse
apolipoprotein O
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BUR5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Gene Ontology Terms (13)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (117)
1 – 10 of 117
CHCHD3
Tbio
Novelty: 0.05341939
Score: 0.979
Data Source: STRINGDB
CHCHD6
Tbio
Novelty: 0.12379343
Score: 0.977
Data Source: STRINGDB
MIC13
Tbio
Novelty: 0.03686888
Score: 0.976
Data Source: STRINGDB
MINOS1
Tdark
Novelty: 0.40437095
Score: 0.975
Data Source: STRINGDB
MTX2
Tbio
Novelty: 0.02047483
Score: 0.973
Data Source: STRINGDB
DNAJC11
Tbio
Novelty: 0.31080011
Score: 0.972
Data Source: STRINGDB
IMMT
Tbio
Novelty: 0.00260309
Score: 0.965
Data Source: STRINGDB
SAMM50
Tbio
Novelty: 0.00553631
Score: 0.962
Data Source: STRINGDB
MTX1
Tbio
Novelty: 0.02350764
Score: 0.962
Data Source: STRINGDB
TMEM11
Tbio
Novelty: 0.00067837
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.27

PubMed score by year
PubTator Score  10.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer