Tbio EFHD1 EF-hand domain-containing protein D1

Protein Summary

Description

Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899). May play a role in neuronal differentiation (By similarity). This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q9BUP0
• B2RD83
• E9PFH3
• Q9BTF8
• Q9H8I2
• Q9HBQ0

Gene Name

• EFHD1

Ensembl ID

• ENST00000264059
• ENSP00000264059
• ENSG00000115468
• ENST00000409613
• ENSP00000386556

Symbol

• SWS2
• SWS2
• MST133
• PP3051
• MSTP133

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
PubMedID	0.83
histone modification site profile	0.82
transcription factor perturbation	0.68
transcription factor binding site profile	0.67

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Ef-hand Domain-containing Protein D1

DTO Classes

Protein / Calcium-binding Protein / Ef-hand Domain-containing Protein D1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.01   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 238   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.01   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0