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Tbio
COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

Protein Summary
Description
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner. The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321998
  • ENSP00000322316
  • ENSG00000167186
  • ENST00000544894
  • ENSP00000442923
  • ENST00000568985
  • ENSP00000456734

Symbol
  • CAT5
  • CLK1
  • CLK-1
  • COQ10D8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
disease perturbation
0.9
histone modification site profile
0.81
cell type or tissue
0.79
gene perturbation
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.82   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.82   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q7, hydroxylase
VGNC:9076
740917
Macaque
coenzyme Q7, hydroxylase
693931
Mouse
MGI:107207
12850
Rat
RGD:2381
25249
Dog
coenzyme Q7, hydroxylase
VGNC:39522
479828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q7, hydroxylase
Macaque
coenzyme Q7, hydroxylase
Mouse
Rat
Dog
coenzyme Q7, hydroxylase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99807-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of cofactors
Reactome
Metabolism of vitamins and cofactors
Reactome
Ubiquinol biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of cofactors
Metabolism of vitamins and cofactors
Ubiquinol biosynthesis
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (74)
1 – 10 of 74
AARS2
Tbio
Family: Enzyme
Novelty: 0.01309387
p_int: 0.860013062
p_ni: 0.139986938
Data Source: BioPlex
COQ9
Tbio
Novelty: 0.00740475
Score: 0.997
Data Source: Reactome,STRINGDB
COQ3
Tbio
Family: Enzyme
Novelty: 0.03013258
Score: 0.996
Data Source: STRINGDB
COQ5
Tbio
Family: Enzyme
Novelty: 0.04664953
Score: 0.993
Data Source: STRINGDB
COQ6
Tbio
Family: Enzyme
Novelty: 0.0290336
Score: 0.968
Data Source: STRINGDB
COQ4
Tbio
Novelty: 0.03537017
Score: 0.954
Data Source: STRINGDB
COQ8A
Tbio
Family: Kinase
Novelty: 0.01672738
Score: 0.934
Data Source: STRINGDB
COQ8B
Tchem
Family: Kinase
Novelty: 0.02469308
Score: 0.933
Data Source: STRINGDB
COQ2
Tbio
Family: Enzyme
Novelty: 0.00575853
Score: 0.909
Data Source: STRINGDB
CLK3
Tchem
Family: Kinase
Novelty: 0.03466191
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  102.82

PubMed score by year
PubTator Score  24.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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