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Tbio
TM9SF2
Transmembrane 9 superfamily member 2

Protein Summary
Description
In the intracellular compartments, may function as a channel or small molecule transporter. This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376387
  • ENSP00000365567
  • ENSG00000125304
  • ENST00000642475
  • ENSP00000493515

Symbol
  • P76
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor binding site profile
0.82
kinase perturbation
0.76
disease perturbation
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.6   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.6   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (42)
1 – 10 of 42
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.853542436
p_ni:  0.146457564
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.78196383
p_ni:  0.21803617
Score:  0.167
Data Source:  BioPlex,STRINGDB
GDPD2
Tbio
Family:  Enzyme
Novelty:  0.07190804
Score:  0.704
Data Source:  STRINGDB
NDST1
Tbio
Family:  Enzyme
Novelty:  0.00955868
Score:  0.667
Data Source:  STRINGDB
IGF2R
Tchem
Novelty:  0.00138374
Score:  0.657
Data Source:  STRINGDB
SLC35B1
Tdark
Family:  Transporter
Novelty:  0.33268269
Score:  0.549
Data Source:  STRINGDB
ZBED1
Tbio
Family:  TF
Novelty:  0.01645222
Score:  0.543
Data Source:  STRINGDB
COPS6
Tbio
Novelty:  0.02653008
Score:  0.54
Data Source:  STRINGDB
KPNA3
Tbio
Novelty:  0.02173035
Score:  0.539
Data Source:  STRINGDB
LACTB2
Tbio
Family:  Enzyme
Novelty:  0.1868172
Score:  0.534
Data Source:  STRINGDB
Gene Ontology Terms (6)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
84.4
eosinophil percentage of leukocytes
1
2
2
82.5
heel bone mineral density
2
2
2
69.6
serum non-albumin protein measurement
1
2
2
50.5
eosinophil count
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
84.4
eosinophil percentage of leukocytes
2
82.5
heel bone mineral density
2
69.6
serum non-albumin protein measurement
2
50.5
eosinophil count
1
21.2
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane 9 superfamily member 2
VGNC:5122
452638
Macaque
transmembrane 9 superfamily member 2
699087
Mouse
MGI:1915309
68059
Rat
RGD:1359230
306197
Dog
transmembrane 9 superfamily member 2
VGNC:47415
476972
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane 9 superfamily member 2
Macaque
transmembrane 9 superfamily member 2
Mouse
Rat
Dog
transmembrane 9 superfamily member 2
Publication Statistics
PubMed Score 5.60
PubMed score by year
PubTator Score 5.95
PubTator score by year