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Tbio
LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

Protein Classes
Protein Summary
Description
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps downregulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005). Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339430
  • ENSP00000340118
  • ENSG00000189067
  • ENST00000381810
  • ENSP00000371231
  • ENST00000413364
  • ENSP00000397958
  • ENST00000570904
  • ENSP00000459138
  • ENST00000571688
  • ENSP00000459533
  • ENST00000574763
  • ENSP00000461813
  • ENST00000576036
  • ENSP00000461667
  • ENST00000620789
  • ENSP00000481589
  • ENST00000622633
  • ENSP00000483114

Symbol
  • PIG7
  • SIMPLE
  • PIG7
  • SIMPLE
  • TP53I7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
1
biological process
0.85
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.18   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.18   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
1
3
94.9
QT interval
6
3
2
1.3
94.6
heel bone mineral density
2
2
2
93.7
electrocardiography
1
2
69
70.4
1
1
0
1.1
68.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
94.9
QT interval
2
1.3
94.6
heel bone mineral density
2
93.7
electrocardiography
69
70.4
0
1.1
68.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipopolysaccharide induced TNF factor
VGNC:9085
453923
Macaque
lipopolysaccharide induced TNF factor
711743
Mouse
MGI:1929512
56722
Rat
RGD:69294
65161
Horse
lipopolysaccharide induced TNF factor
VGNC:19691
100033923
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipopolysaccharide induced TNF factor
Macaque
lipopolysaccharide induced TNF factor
Mouse
Rat
Horse
lipopolysaccharide induced TNF factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99732-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (22)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (81)
1 – 10 of 81
R3HDM1
Tdark
Novelty: 0.19586369
p_int: 0.999997941
p_ni: 0.000001718
p_wrong: 3.41e-7
Score: 0.232
Data Source: BioPlex,STRINGDB
HPCAL4
Tdark
Novelty: 0.26673582
p_int: 0.999997724
p_ni: 6.89e-7
p_wrong: 0.000001587
Score: 0.165
Data Source: BioPlex,STRINGDB
CYHR1
Tdark
Novelty: 0.04771996
p_int: 0.999846054
p_ni: 0.000125469
p_wrong: 0.000028477
Data Source: BioPlex
BCS1L
Tbio
Family: Enzyme
Novelty: 0.01764582
p_int: 0.999535551
p_ni: 0.000464449
Data Source: BioPlex
UBB
Tbio
Novelty: 0.00661254
p_int: 0.999194144
p_ni: 0.000805856
Data Source: BioPlex
PUM2
Tbio
Novelty: 0.01849765
p_int: 0.998076275
p_ni: 0.000950164
p_wrong: 0.000973561
Data Source: BioPlex
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
p_int: 0.998067397
p_ni: 0.001928295
p_wrong: 0.000004308
Data Source: BioPlex
PTPRD
Tbio
Family: Enzyme
Novelty: 0.01059407
p_int: 0.990420707
p_ni: 0.00953566
p_wrong: 0.000043633
Data Source: BioPlex
LRP10
Tbio
Novelty: 0.04049684
p_int: 0.986911853
p_ni: 0.013088115
p_wrong: 3.2e-8
Data Source: BioPlex
APOB
Tchem
Novelty: 0.00008247
p_int: 0.978465593
p_ni: 0.021534407
Data Source: BioPlex
Publication Statistics
PubMed Score  120.18

PubMed score by year
PubTator Score  52.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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