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Tbio
RIT2
GTP-binding protein Rit2

Protein Summary
Description
Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326695
  • ENSP00000321805
  • ENSG00000152214
  • ENST00000589109
  • ENSP00000467217

Symbol
  • RIN
  • ROC2
  • RIN
  • RIBA
  • ROC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
trait
0.75
cell type or tissue
0.65
phenotype
0.65
gene perturbation
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.43   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.43   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
1
1.1
89.4
lifestyle measurement
1
1
1
76.4
disease progression measurement
1
1
0
19.2
47
metastasis measurement
1
1
0
19.2
47
metastatic colorectal cancer
1
1
0
19.2
47
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
89.4
lifestyle measurement
1
76.4
disease progression measurement
0
19.2
47
metastasis measurement
0
19.2
47
metastatic colorectal cancer
0
19.2
47
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras like without CAAX 2
VGNC:13279
737881
Mouse
MGI:108054
19762
Rat
RGD:1307654
291713
Dog
Ras like without CAAX 2
VGNC:45601
490475
Horse
Ras like without CAAX 2
VGNC:22406
100053080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras like without CAAX 2
Mouse
Rat
Dog
Ras like without CAAX 2
Horse
Ras like without CAAX 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99578-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by NTRK1 (TRKA)
Reactome
Signaling by NTRKs
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signalling to ERKs
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by NTRK1 (TRKA)
Signaling by NTRKs
Signaling by Receptor Tyrosine Kinases
Signalling to ERKs
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (109)
1 – 10 of 109
RIT1
Tbio
Family: Enzyme
Novelty: 0.02780594
p_int: 0.999005573
p_ni: 0.000004359
p_wrong: 0.000990068
Score: 0.988
Data Source: BioPlex,STRINGDB
LZTR1
Tbio
Novelty: 0.02363333
p_int: 0.967276961
p_ni: 0.032722814
p_wrong: 2.25e-7
Score: 0.855
Data Source: BioPlex,STRINGDB
NTRK2
Tclin
Family: Kinase
Novelty: 0.00054534
Score: 0.933
Data Source: STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
Score: 0.93
Data Source: Reactome,STRINGDB
NTRK3
Tclin
Family: Kinase
Novelty: 0.00177321
Score: 0.926
Data Source: STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.917
Data Source: Reactome,STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.903
Data Source: STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.901
Data Source: Reactome,STRINGDB
NTF4
Tbio
Novelty: 0.00192875
Score: 0.9
Data Source: STRINGDB
NTF3
Tbio
Novelty: 0.00089023
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.43

PubMed score by year
PubTator Score  452.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer