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Tbio
FMO2
Dimethylaniline monooxygenase [N-oxide-forming] 2

Protein Summary
Description
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000209929
  • ENSP00000209929
  • ENSG00000094963

Symbol
  • FMO1B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.71
molecular function
0.67
PubMedID
0.67
pathway
0.63
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.21   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.21   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (20)
1 – 10 of 20
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.806007942
p_ni:  0.193990174
p_wrong:  0.000001884
Score:  0.187
Data Source:  BioPlex,STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.933
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.93
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.928
Data Source:  STRINGDB
NPR1
Tclin
Family:  Kinase
Novelty:  0.00170829
Score:  0.663
Data Source:  STRINGDB
GJA5
Tbio
Novelty:  0.00195794
Score:  0.568
Data Source:  STRINGDB
TG
Tbio
Novelty:  0.00010111
Score:  0.538
Data Source:  STRINGDB
CYP2C8
Tchem
Novelty:  0.00186373
Score:  0.469
Data Source:  STRINGDB
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.462
Data Source:  STRINGDB
CYP3A7
Tclin
Family:  Enzyme
Novelty:  0.00736888
Score:  0.456
Data Source:  STRINGDB
Pathways (7)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
FMO oxidises nucleophiles
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
FMO oxidises nucleophiles
Metabolism
Phase I - Functionalization of compounds
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
81.2
blood metabolite measurement
1
1
1
59.6
myeloid white cell count
1
1
1
49.5
testosterone measurement
1
1
1
48.5
lentiform nucleus measurement
1
1
0
112.3
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
81.2
blood metabolite measurement
1
59.6
myeloid white cell count
1
49.5
testosterone measurement
1
48.5
lentiform nucleus measurement
0
112.3
0.7
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 2
VGNC:543
449587
Macaque
flavin containing monooxygenase 2
703639
Mouse
MGI:1916776
55990
Rat
RGD:628600
246245
Dog
flavin containing monooxygenase 2
VGNC:40917
480076
Species
Name
OMA
EggNOG
Inparanoid
Chimp
flavin containing monooxygenase 2
Macaque
flavin containing monooxygenase 2
Mouse
Rat
Dog
flavin containing monooxygenase 2
Publication Statistics
PubMed Score 37.21
PubMed score by year
PubTator Score 40.74
PubTator score by year