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Tbio
CCNL2
Cyclin-L2

Protein Summary
Description
Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400809
  • ENSP00000383611
  • ENSG00000221978
  • ENST00000408918
  • ENSP00000386158
  • ENST00000481223
  • ENSP00000423734
  • ENST00000488340
  • ENSP00000424647

Symbol
  • CCNM
  • CCNS
  • PCEE
  • SB138
  • ANIA-6B
  • HLA-ISO
  • HCLA-ISO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor binding site profile
0.9
histone modification site profile
0.81
tissue sample
0.68
tissue
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.07   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.07   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
56.2
intraocular pressure measurement
1
2
2
52.7
1
1
0
1.1
35
heel bone mineral density
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.2
intraocular pressure measurement
2
52.7
0
1.1
35
heel bone mineral density
1
6.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin L2
VGNC:5003
457972
Macaque
cyclin L2
701413
Mouse
MGI:1927119
56036
Rat
Dog
cyclin L2
VGNC:38905
479570
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin L2
Macaque
cyclin L2
Mouse
Rat
Dog
cyclin L2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96S94-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (100)
1 – 10 of 100
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999999272
p_ni:  7.1e-7
p_wrong:  1.8e-8
Data Source:  BioPlex
LRRTM4
Tbio
Novelty:  0.07741851
p_int:  0.9999942
p_ni:  0.000005235
p_wrong:  5.66e-7
Data Source:  BioPlex
CDK11A
Tchem
Family:  Kinase
Novelty:  0.02312993
p_int:  0.99999304
p_ni:  0.000006929
p_wrong:  3.1e-8
Score:  0.844
Data Source:  BioPlex,STRINGDB
CCNY
Tbio
Novelty:  0.01400663
p_int:  0.999829866
p_ni:  0.000170117
p_wrong:  1.7e-8
Score:  0.731
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.999736191
p_ni:  0.000263809
Data Source:  BioPlex
IRF2BP1
Tdark
Novelty:  0.29719488
p_int:  0.999395255
p_ni:  0.000541471
p_wrong:  0.000063274
Score:  0.546
Data Source:  BioPlex,STRINGDB
IREB2
Tbio
Novelty:  0.00300491
p_int:  0.996226336
p_ni:  0.003773663
Score:  0.174
Data Source:  BioPlex,STRINGDB
NF2
Tbio
Novelty:  0.00055092
p_int:  0.995547343
p_ni:  0.004397645
p_wrong:  0.000055012
Score:  0.181
Data Source:  BioPlex,STRINGDB
OCC1
Tbio
Novelty:  0.05175429
p_int:  0.988116997
p_ni:  0.010536038
p_wrong:  0.001346965
Score:  0.185
Data Source:  BioPlex,STRINGDB
ZBTB43
Tdark
Family:  TF
Novelty:  0.35735342
p_int:  0.987903341
p_ni:  0.000042362
p_wrong:  0.012054297
Score:  0.212
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  28.07

PubMed score by year
PubTator Score  12.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer