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Tbio
SPAG5
Sperm-associated antigen 5

Protein Summary
Description
Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321765
  • ENSP00000323300
  • ENSG00000076382

Symbol
  • MAP126
  • DEEPEST
  • hMAP126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
protein complex
0.85
tissue
0.72
cellular component
0.69
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.01   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.01   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
36.9
tonsillectomy risk measurement
1
1
0
1.1
24.5
urate measurement
1
1
1
21.5
insomnia measurement
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
36.9
tonsillectomy risk measurement
0
1.1
24.5
urate measurement
1
21.5
insomnia measurement
0
1.1
21.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sperm associated antigen 5
VGNC:9645
104002889
Macaque
sperm associated antigen 5
709400
Mouse
MGI:1927470
54141
Rat
Dog
sperm associated antigen 5
480623
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sperm associated antigen 5
Macaque
sperm associated antigen 5
Mouse
Rat
Dog
sperm associated antigen 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96R06-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (221)
1 – 10 of 221
RINT1
Tbio
Novelty:  0.04546291
p_int:  0.999984763
p_ni:  0.000015237
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999969352
p_ni:  0.000030648
Data Source:  BioPlex
DEUP1
Tbio
Novelty:  0.13274391
p_int:  0.999965819
p_ni:  0.000034181
Score:  0.16
Data Source:  BioPlex,STRINGDB
MYCBP
Tbio
Novelty:  0.03202836
p_int:  0.999957012
p_ni:  0.000042988
Data Source:  BioPlex
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999952293
p_ni:  0.000047707
Data Source:  BioPlex
COPS7B
Tbio
Novelty:  0.63421506
p_int:  0.999934754
p_ni:  0.000065246
Data Source:  BioPlex
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.999890066
p_ni:  0.000109934
Data Source:  BioPlex
FSD2
Tbio
Novelty:  0.1302271
p_int:  0.999777352
p_ni:  0.000222648
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999162306
p_ni:  0.000837694
Score:  0.362
Data Source:  BioPlex,STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.99913459
p_ni:  0.00086541
Data Source:  BioPlex
Publication Statistics
PubMed Score  51.01

PubMed score by year
PubTator Score  28.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer