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Tbio
ODF3
Outer dense fiber protein 3

Protein Summary
Description
Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail. ODF3 is a component of sperm flagella outer dense fibers, which add stiffness, elastic recoil, and protection against shearing forces during sperm movement.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325113
  • ENSP00000325868
  • ENSG00000177947
  • ENST00000525282
  • ENSP00000436588

Symbol
  • SHIPPO1
  • TISP50
  • CT135
  • TISP50
  • SHIPPO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
tissue sample
0.57
cell type or tissue
0.51
cell line
0.43
cellular component
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.44   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.44   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
6
9
99.4
platelet count
5
4
3
4.7
98.4
mean corpuscular volume
3
3
3
92.1
5
5
0
1.2
91.4
alkaline phosphatase measurement
2
2
2
17.9
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99.4
platelet count
3
4.7
98.4
mean corpuscular volume
3
92.1
0
1.2
91.4
alkaline phosphatase measurement
2
17.9
90.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
outer dense fiber of sperm tails 3
VGNC:1079
738253
Macaque
outer dense fiber of sperm tails 3
696480
Mouse
MGI:1916537
69287
Rat
RGD:1310028
365387
Dog
outer dense fiber of sperm tails 3
VGNC:44101
483392
Species
Name
OMA
EggNOG
Inparanoid
Chimp
outer dense fiber of sperm tails 3
Macaque
outer dense fiber of sperm tails 3
Mouse
Rat
Dog
outer dense fiber of sperm tails 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96PU9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (51)
1 – 10 of 51
ANKRD50
Tdark
Novelty:  0.7929169
p_int:  0.999999945
p_ni:  5.5e-8
Data Source:  BioPlex
MMADHC
Tbio
Novelty:  0.02299238
p_int:  0.997066779
p_ni:  0.002047061
p_wrong:  0.00088616
Data Source:  BioPlex
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.934827385
p_ni:  0.064566737
p_wrong:  0.000605878
Data Source:  BioPlex
PSMG4
Tdark
Novelty:  0.05339077
p_int:  0.87122073
p_ni:  0.125710087
p_wrong:  0.003069183
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.81224762
p_ni:  0.18775238
Data Source:  BioPlex
C12orf57
Tbio
Novelty:  0.00353824
p_int:  0.772977714
p_ni:  0.000223325
p_wrong:  0.22679896
Data Source:  BioPlex
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.767321705
p_ni:  0.232678295
Score:  0.223
Data Source:  BioPlex,STRINGDB
ODF4
Tbio
Novelty:  0.13423621
Score:  0.725
Data Source:  STRINGDB
EVI5
Tbio
Novelty:  0.05021983
Score:  0.703
Data Source:  STRINGDB
ODF2
Tbio
Novelty:  0.03203587
Score:  0.697
Data Source:  STRINGDB
Publication Statistics
PubMed Score  12.44

PubMed score by year
PubTator Score  3.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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