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Tbio
FCRL3
Fc receptor-like protein 3

Protein Summary
Description
Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275). This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-ty ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368184
  • ENSP00000357167
  • ENSG00000160856
  • ENST00000368186
  • ENSP00000357169
  • ENST00000477837
  • ENSP00000433430
  • ENST00000485028
  • ENSP00000434331
  • ENST00000492769
  • ENSP00000435487

Symbol
  • FCRH3
  • IFGP3
  • IRTA3
  • SPAP2
  • FCRH3
  • IFGP3
  • IRTA3
  • SPAP2
  • CD307c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.81
tissue
0.59
protein domain
0.58
disease
0.57
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.08   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.08   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.776950338
p_ni:  0.223049662
Score:  0.179
Data Source:  BioPlex,STRINGDB
PIGR
Tbio
Novelty:  0.0025812
Score:  0.753
Data Source:  STRINGDB
PTPN22
Tchem
Family:  Enzyme
Novelty:  0.00168847
Score:  0.722
Data Source:  STRINGDB
TSHR
Tclin
Family:  GPCR
Novelty:  0.00074972
Score:  0.609
Data Source:  STRINGDB
PADI4
Tchem
Family:  Enzyme
Novelty:  0.0024252
Score:  0.598
Data Source:  STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
Score:  0.554
Data Source:  STRINGDB
PTPN6
Tchem
Family:  Enzyme
Novelty:  0.00535749
Score:  0.536
Data Source:  STRINGDB
KIAA1143
Tdark
Novelty:  3.96985921
Score:  0.531
Data Source:  STRINGDB
RNASET2
Tbio
Family:  Enzyme
Novelty:  0.01939252
Score:  0.521
Data Source:  STRINGDB
P01911
Tchem
Novelty:  0.00240724
Score:  0.511
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
68.5
1
1
0
1.2
58.4
2
2
1
1.1
29
autoantibody measurement
1
1
0
1.4
6.1
1
1
0
1.1
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
68.5
0
1.2
58.4
1
1.1
29
autoantibody measurement
0
1.4
6.1
0
1.1
3.2
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fc receptor like 3
VGNC:6821
469519
Horse
Fc receptor like 3
VGNC:50834
100054212
Cow
Fc receptor like 3
VGNC:50048
515085
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fc receptor like 3
Horse
Fc receptor like 3
Cow
Fc receptor like 3
Publication Statistics
PubMed Score 86.08
PubMed score by year
PubTator Score 75.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title