Tbio FCRL3 Fc receptor-like protein 3

Protein Summary

Description

Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275). This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q96P31
• A0N0M4
• A8MTH7
• D3DVD2
• Q5VXZ8
• Q8N6S2
• Q96LA4
• Q96P27
• Q96P28
• Q96P29
• Q96P30
• FcR-like protein 3

Gene Name

• FCRL3

Ensembl ID

• ENST00000368184
• ENSP00000357167
• ENSG00000160856
• ENST00000368186
• ENSP00000357169
• ENST00000477837
• ENSP00000433430
• ENST00000485028
• ENSP00000434331
• ENST00000492769
• ENSP00000435487

Symbol

• FCRH3
• IFGP3
• IRTA3
• SPAP2
• FCRH3
• IFGP3
• IRTA3
• SPAP2
• CD307c

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.81
tissue	0.59
protein domain	0.58
disease	0.57
cell line	0.55

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.08   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.08   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (39)

Explore Interacting Targets

1 – 10 of 39

• See Interactions on String-DB

HSPA8

Tchem

Novelty:  0.00081014

p_int:  0.776950338

p_ni:  0.223049662

Score:  0.179

Data Source:  BioPlex,STRINGDB

PIGR

Tbio

Novelty:  0.0025812

Score:  0.753

Data Source:  STRINGDB

PTPN22

Tchem

Family:  Enzyme

Novelty:  0.00168847

Score:  0.722

Data Source:  STRINGDB

TSHR

Tclin

Family:  GPCR

Novelty:  0.00074972

Score:  0.609

Data Source:  STRINGDB

PADI4

Tchem

Family:  Enzyme

Novelty:  0.0024252

Score:  0.598

Data Source:  STRINGDB

CTLA4

Tclin

Novelty:  0.00012781

Score:  0.554

Data Source:  STRINGDB

PTPN6

Tchem

Family:  Enzyme

Novelty:  0.00535749

Score:  0.536

Data Source:  STRINGDB

KIAA1143

Tdark

Novelty:  3.96985921

Score:  0.531

Data Source:  STRINGDB

RNASET2

Tbio

Family:  Enzyme

Novelty:  0.01939252

Score:  0.521

Data Source:  STRINGDB

HLA-DRB1

Tchem

Novelty:  0.00240724

Score:  0.511

Data Source:  STRINGDB

Pathways (1)

PathwayCommons (1)

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1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: netpath	TCR	258 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
TCR	258 targets	PathwayCommons: netpath

Gene Ontology Terms (16)

Functions (4)

Components (3)

Processes (9)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
phosphatase binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein phosphatase binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein tyrosine kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
multiple sclerosis	EFO_0003885	2	2	0	1.1	68.5
Graves disease	EFO_0004237	1	1	0	1.2	58.4
rheumatoid arthritis	EFO_0000685	2	2	1	1.1	29
autoantibody measurement	EFO_0004866	1	1	0	1.4	6.1
IGA glomerulonephritis	EFO_0004194	1	1	0	1.1	3.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
multiple sclerosis	EFO_0003885	0	1.1	68.5
Graves disease	EFO_0004237	0	1.2	58.4
rheumatoid arthritis	EFO_0000685	1	1.1	29
autoantibody measurement	EFO_0004866	0	1.4	6.1
IGA glomerulonephritis	EFO_0004194	0	1.1	3.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor

GWAS Trait Find Similar Targets

No Header	No Header
autoantibody measurement
Graves disease
IGA glomerulonephritis
multiple sclerosis
rheumatoid arthritis

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Fc receptor like 3	VGNC:6821	469519
Horse	Fc receptor like 3	VGNC:50834	100054212
Cow	Fc receptor like 3	VGNC:50048	515085

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Fc receptor like 3
Horse	Fc receptor like 3
Cow	Fc receptor like 3

Publication Statistics

PubMed Score 86.08

PubMed score by year

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PubTator Score 75.33

PubTator score by year

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