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Tbio
RPGRIP1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

Protein Summary
Description
May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells. This gene encodes a photoreceptor protein that interacts with retinitis pigmentosa GTPase regulator protein and is a key component of cone and rod photoreceptor cells. Mutations in this gene lead to autosomal recessive congenital blindness. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382933
  • ENSP00000372391
  • ENSG00000092200
  • ENST00000400017
  • ENSP00000382895

Symbol
  • LCA6
  • RGI1
  • RGRIP
  • CORD13
  • RPGRIP
  • RPGRIP1d
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
virus perturbation
0.72
tissue sample
0.62
co-expressed gene
0.57
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.38   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.38   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
RPGR
Tbio
Family:  Enzyme
Novelty:  0.002733
Score:  0.983
Data Source:  STRINGDB
NPHP4
Tbio
Novelty:  0.02873746
Score:  0.971
Data Source:  STRINGDB
AIPL1
Tbio
Novelty:  0.01436649
Score:  0.79
Data Source:  STRINGDB
RAB40AL
Tbio
Novelty:  0.00908832
Score:  0.71
Data Source:  STRINGDB
NEK4
Tchem
Family:  Kinase
Novelty:  0.05805595
Score:  0.692
Data Source:  STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.677
Data Source:  STRINGDB
LCA5
Tbio
Novelty:  0.0379066
Score:  0.676
Data Source:  STRINGDB
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.671
Data Source:  STRINGDB
IQCB1
Tbio
Novelty:  0.02979098
Score:  0.67
Data Source:  STRINGDB
SPATA7
Tbio
Novelty:  0.07689485
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
47.7
mathematical ability
1
1
1
35
electrocardiography
1
1
1
14.2
body height
1
1
1
12.7
C-reactive protein measurement
1
1
1
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
47.7
mathematical ability
1
35
electrocardiography
1
14.2
body height
1
12.7
C-reactive protein measurement
1
3.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RPGR interacting protein 1
VGNC:3322
473331
Macaque
RPGR interacting protein 1
707961
Mouse
MGI:1932134
77945
Dog
RPGR interacting protein 1
VGNC:45711
475400
Horse
RPGR interacting protein 1
VGNC:22517
100072725
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RPGR interacting protein 1
Macaque
RPGR interacting protein 1
Mouse
Dog
RPGR interacting protein 1
Horse
RPGR interacting protein 1
Publication Statistics
PubMed Score 28.38
PubMed score by year
PubTator Score 46.02
PubTator score by year
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Related Publications
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PMID
Year
Title