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Tbio
SERAC1
Protein SERAC1

Protein Summary
Description
Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway. The protein encoded by this gene is a phosphatidylglycerol remodeling protein found at the interface of mitochondria and endoplasmic reticula, where it mediates phospholipid exchange. The encoded protein plays a major role in mitochondrial function and intracellular cholesterol trafficking. Defects in this gene are a cause of 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367101
  • ENSP00000356068
  • ENSG00000122335
  • ENST00000367104
  • ENSP00000356071
  • ENST00000647468
  • ENSP00000496731
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor perturbation
0.74
tissue sample
0.67
microRNA
0.61
tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.78   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.78   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.83655615
p_ni:  0.16344385
Score:  0.224
Data Source:  BioPlex,STRINGDB
DNAJC19
Tbio
Family:  Enzyme
Novelty:  0.02938164
Score:  0.714
Data Source:  STRINGDB
BCS1L
Tbio
Family:  Enzyme
Novelty:  0.01764582
Score:  0.694
Data Source:  STRINGDB
MROH6
Tdark
Novelty:  4.12919512
Score:  0.671
Data Source:  STRINGDB
AGK
Tbio
Family:  Enzyme
Novelty:  0.00919083
Score:  0.665
Data Source:  STRINGDB
FGFBP2
Tbio
Novelty:  0.17105915
Score:  0.65
Data Source:  STRINGDB
HEATR9
Tdark
Novelty:  0.71415315
Score:  0.645
Data Source:  STRINGDB
TMEM70
Tbio
Novelty:  0.03111438
Score:  0.636
Data Source:  STRINGDB
CHKB
Tbio
Family:  Kinase
Novelty:  0.00862294
Score:  0.635
Data Source:  STRINGDB
TOGARAM1
Tdark
Novelty:  0.23837453
Score:  0.612
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
74.2
age-related hearing impairment
1
1
0
7.1
55.2
lipoprotein A measurement
1
1
1
39.6
intraocular pressure measurement
1
1
1
31.4
cognitive function measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
74.2
age-related hearing impairment
0
7.1
55.2
lipoprotein A measurement
1
39.6
intraocular pressure measurement
1
31.4
cognitive function measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine active site containing 1
VGNC:3699
104007060
Macaque
serine active site containing 1
705523
Mouse
MGI:2447813
321007
Rat
RGD:1565064
499015
Dog
serine active site containing 1
VGNC:46017
476255
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine active site containing 1
Macaque
serine active site containing 1
Mouse
Rat
Dog
serine active site containing 1
Publication Statistics
PubMed Score 29.78
PubMed score by year
PubTator Score 20.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title