Tdark ZNF333 Zinc finger protein 333

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q96JL9
• Q6P2E6
• Q86WS6
• Q8TDL0

Gene Name

• ZNF333

Ensembl ID

• ENST00000292530
• ENSP00000292530
• ENSG00000160961
• ENST00000540689
• ENSP00000438130

Symbol

• KIAA1806

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.75
microRNA	0.59
protein domain	0.58
cell line	0.47
tissue	0.44

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.37   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.37   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Gene Ontology Terms (4)

Functions (3)

Components (1)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (11)

Explore Interacting Targets

1 – 10 of 11

• See Interactions on String-DB

ARL15

Tbio

Family: Enzyme

Novelty: 0.0602724

p_int: 0.998195838

p_ni: 0.001782107

p_wrong: 0.000022055

Score: 0.349

Data Source: BioPlex,STRINGDB

ASPM

Tbio

Novelty: 0.00712035

p_int: 0.903587099

p_ni: 0.096412901

Score: 0.207

Data Source: BioPlex,STRINGDB

TRIM28

Tbio

Family: Epigenetic

Novelty: 0.01042773

Score: 0.968

Data Source: STRINGDB

TMEM44

Tdark

Novelty: 9

Score: 0.711

Data Source: STRINGDB

RHOBTB2

Tbio

Novelty: 0.01298176

Score: 0.489

Data Source: STRINGDB

ZNF385B

Tbio

Novelty: 0.25732666

Score: 0.463

Data Source: STRINGDB

NFATC2

Tbio

Family: TF

Novelty: 0.00358612

Score: 0.44

Data Source: STRINGDB

ING4

Tbio

Family: Epigenetic

Novelty: 0.01571567

Score: 0.433

Data Source: STRINGDB

ZNF474

Tdark

Novelty: 1.5

Score: 0.42

Data Source: STRINGDB

ADAMTS14

Tbio

Family: Enzyme

Novelty: 0.08828132

Score: 0.42

Data Source: STRINGDB

Publication Statistics

PubMed Score  2.37

PubMed score by year

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PubTator Score  2.96

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MESVTFEDVAVEFIQEWALLDSARRSLCKYRMLDQCRTLASRGTPPCKPSCVSQLGQRAEPKATERGILR

1-70

ATGVAWESQLKPEELPSMQDLLEEASSRDMQMGPGLFLRMQLVPSIEERETPLTREDRPALQEPPWSLGC

70-140

TGLKAAMQIQRVVIPVPTLGHRNPWVARDSAVPARDPAWLQEDKVEEEAMAPGLPTACSQEPVTFADVAV

140-210

VFTPEEWVFLDSTQRSLYRDVMLENYRNLASVADQLCKPNALSYLEERGEQWTTDRGVLSDTCAEPQCQP

210-280

QEAIPSQDTFTEILSIDVKGEQPQPGEKLYKYNELEKPFNSIEPLFQYQRIHAGEASCECQEIRNSFFQS

280-350

AHLIVPEKIRSGDKSYACNKCEKSFRYSSDLIRHEKTHTAEKCFDCQECGQAFKYSSNLRRHMRTHTGEK

350-420

PFECSQCGKTFTRNFNLILHQRNHTGEKPYECKDCGKAFNQPSSLRSHVRTHTGEKPFECSQCGKAFREH

420-490

SSLKTHLRTHTREKPYECNQCGKPFRTSTHLNVHKRIHTGEKLYECATCGQVLSRLSTLKSHMRTHTGEK

490-560

PYVCQECGRAFSEPSSLRKHARTHSGKKPYACQECGRAFGQSSHLIVHVRTHSAGRPYQCNQCEKAFRHS

560-630

SSLTVHKRTHVGRETIRNGSLPLSMSHPYCGPLAN

630-665

MESVTFEDVAVEFIQEWALLDSARRSLCKYRMLDQCRTLASRGTPPCKPSCVSQLGQRAEPKATERGILRATGVAWESQLKPEELPSMQDLLEEASSRDMQMGPGLFLRMQLVPSIEERETPLTREDRPALQEPPWSLGCTGLKAAMQIQRVVIPVPTLGHRNPWVARDSAVPARDPAWLQEDKVEEEAMAPGLPTACSQEPVTFADVAVVFTPEEWVFLDSTQRSLYRDVMLENYRNLASVADQLCKPNALSYLEERGEQWTTDRGVLSDTCAEPQCQPQEAIPSQDTFTEILSIDVKGEQPQPGEKLYKYNELEKPFNSIEPLFQYQRIHAGEASCECQEIRNSFFQSAHLIVPEKIRSGDKSYACNKCEKSFRYSSDLIRHEKTHTAEKCFDCQECGQAFKYSSNLRRHMRTHTGEKPFECSQCGKTFTRNFNLILHQRNHTGEKPYECKDCGKAFNQPSSLRSHVRTHTGEKPFECSQCGKAFREHSSLKTHLRTHTREKPYECNQCGKPFRTSTHLNVHKRIHTGEKLYECATCGQVLSRLSTLKSHMRTHTGEKPYVCQECGRAFSEPSSLRKHARTHSGKKPYACQECGRAFGQSSHLIVHVRTHSAGRPYQCNQCEKAFRHSSSLTVHKRTHVGRETIRNGSLPLSMSHPYCGPLAN

Find similar targets by:

Uniprot Keyword

Alternative splicing
Complete proteome
DNA-binding
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation