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Tbio
TMX3
Protein disulfide-isomerase TMX3

Protein Summary
Description
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299608
  • ENSP00000299608
  • ENSG00000166479
  • ENST00000562706
  • ENSP00000457262

Symbol
  • KIAA1830
  • TXNDC10
  • PDIA13
  • TXNDC10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.74
transcription factor perturbation
0.74
tissue
0.73
cell type or tissue
0.62
tissue sample
0.62


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.03   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.03   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin related transmembrane protein 3
VGNC:7334
739978
Macaque
thioredoxin related transmembrane protein 3
710611
Mouse
MGI:2442418
67988
Rat
RGD:1592777
682967
Dog
thioredoxin related transmembrane protein 3
VGNC:47644
476176
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin related transmembrane protein 3
Macaque
thioredoxin related transmembrane protein 3
Mouse
Rat
Dog
thioredoxin related transmembrane protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JJ7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (36)
1 – 10 of 36
AP1G2
Tbio
Novelty:  0.17203425
p_int:  0.912915152
p_ni:  0.087084848
Score:  0.39
Data Source:  BioPlex,STRINGDB
UNC50
Tbio
Novelty:  0.03652325
Score:  0.756
Data Source:  STRINGDB
TXNDC12
Tbio
Novelty:  0.01354011
Score:  0.713
Data Source:  STRINGDB
RIC3
Tbio
Novelty:  0.0162412
Score:  0.658
Data Source:  STRINGDB
ERP29
Tbio
Novelty:  0.0132632
Score:  0.621
Data Source:  STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
Score:  0.616
Data Source:  STRINGDB
TMEM252
Tdark
Novelty:  0.5615322
Score:  0.605
Data Source:  STRINGDB
RTTN
Tbio
Novelty:  0.04524944
Score:  0.58
Data Source:  STRINGDB
CANX
Tbio
Novelty:  0.00087002
Score:  0.57
Data Source:  STRINGDB
CCDC102A
Tdark
Novelty:  1.89784272
Score:  0.57
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.03

PubMed score by year
PubTator Score  5.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer