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Tdark
ZNF414
Zinc finger protein 414

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255616
  • ENSP00000255616
  • ENSG00000133250
  • ENST00000393927
  • ENSP00000377504

Symbol
  • ZFP414
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
tissue sample
0.67
kinase perturbation
0.66
transcription factor binding site profile
0.59
transcription factor
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.52   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
KDM4B
Tchem
Family:  Epigenetic
Novelty:  0.01615072
p_int:  0.999999646
p_ni:  3.52e-7
p_wrong:  2e-9
Score:  0.57
Data Source:  BioPlex,STRINGDB
KDM4A
Tchem
Family:  Epigenetic
Novelty:  0.00643043
p_int:  0.999999501
p_ni:  4.95e-7
p_wrong:  4e-9
Score:  0.58
Data Source:  BioPlex,STRINGDB
ZRANB1
Tbio
Family:  Enzyme
Novelty:  0.07721072
p_int:  0.999997125
p_ni:  0.000002462
p_wrong:  4.12e-7
Score:  0.206
Data Source:  BioPlex,STRINGDB
ANKRD50
Tdark
Novelty:  0.7929169
p_int:  0.999996481
p_ni:  0.000003024
p_wrong:  4.96e-7
Score:  0.24
Data Source:  BioPlex,STRINGDB
NOC4L
Tdark
Novelty:  0.39929311
p_int:  0.999983568
p_ni:  0.000016432
Data Source:  BioPlex
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.999965527
p_ni:  0.000034472
p_wrong:  1e-9
Data Source:  BioPlex
NOP14
Tbio
Novelty:  0.08903014
p_int:  0.999946235
p_ni:  0.000053765
Data Source:  BioPlex
HSD17B8
Tbio
Family:  Enzyme
Novelty:  0.00915958
p_int:  0.999932539
p_ni:  0.000051255
p_wrong:  0.000016206
Data Source:  BioPlex
NPRL2
Tbio
Family:  Enzyme
Novelty:  0.02848752
p_int:  0.999887821
p_ni:  0.000112179
Score:  0.513
Data Source:  BioPlex,STRINGDB
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.999565341
p_ni:  0.000434659
Score:  0.196
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
5
8
13
97.6
BMI-adjusted hip circumference
2
6
8
96.7
body weights and measures
1
1
1
87.6
body fat distribution
3
1
5
83.5
basophil count
2
2
2
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
13
97.6
BMI-adjusted hip circumference
8
96.7
body weights and measures
1
87.6
body fat distribution
5
83.5
basophil count
2
79.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 414
VGNC:2177
743829
Macaque
zinc finger protein 414
707889
Mouse
MGI:1915641
328801
Rat
RGD:1308123
299647
Dog
zinc finger protein 414
VGNC:54390
611636
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 414
Macaque
zinc finger protein 414
Mouse
Rat
Dog
zinc finger protein 414
Publication Statistics
PubMed Score 0.52
PubMed score by year
PubTator Score 0.33
PubTator score by year
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Related Publications
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PMID
Year
Title