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Tbio
NARS2
Probable asparagine--tRNA ligase, mitochondrial

Protein Summary
Description
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). [provided by RefSeq, Mar 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281038
  • ENSP00000281038
  • ENSG00000137513
  • ENST00000528850
  • ENSP00000432635

Symbol
  • SLM5
  • asnRS
  • DFNB94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
kinase perturbation
0.88
histone modification site profile
0.86
transcription factor binding site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.999631921
p_ni:  0.000368005
p_wrong:  7.4e-8
Data Source:  BioPlex
RAB8B
Tbio
Family:  Enzyme
Novelty:  0.06230082
p_int:  0.999610397
p_ni:  0.000389603
Score:  0.157
Data Source:  BioPlex,STRINGDB
PDK4
Tchem
Family:  Kinase
Novelty:  0.00410067
p_int:  0.997701737
p_ni:  0.002298262
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.997521491
p_ni:  0.002477865
p_wrong:  6.44e-7
Data Source:  BioPlex
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.99731945
p_ni:  0.002662753
p_wrong:  0.000017798
Score:  0.17
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.995654452
p_ni:  0.004329723
p_wrong:  0.000015826
Score:  0.371
Data Source:  BioPlex,STRINGDB
MRPL23
Tdark
Novelty:  0.16745043
p_int:  0.989461017
p_ni:  0.010533499
p_wrong:  0.000005484
Data Source:  BioPlex
ACSM5
Tbio
Family:  Enzyme
Novelty:  0.11562771
p_int:  0.987440794
p_ni:  0.012555817
p_wrong:  0.000003389
Score:  0.172
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.984353853
p_ni:  0.015646145
p_wrong:  2e-9
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.964759763
p_ni:  0.03523945
p_wrong:  7.87e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
1
0
1.1
85.5
age at menarche
2
2
1
3.1
85.3
Alzheimer disease
1
1
0
4.1
70.4
aspartate aminotransferase measurement
1
1
0
10
66.2
hair colour measurement
1
1
1
65.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
85.5
age at menarche
1
3.1
85.3
Alzheimer disease
0
4.1
70.4
aspartate aminotransferase measurement
0
10
66.2
hair colour measurement
1
65.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
asparaginyl-tRNA synthetase 2, mitochondrial
VGNC:48980
466723
Macaque
asparaginyl-tRNA synthetase 2, mitochondrial
700326
Mouse
MGI:2142075
244141
Rat
RGD:1305145
293128
Horse
asparaginyl-tRNA synthetase 2, mitochondrial
VGNC:50487
100062849
Species
Name
OMA
EggNOG
Inparanoid
Chimp
asparaginyl-tRNA synthetase 2, mitochondrial
Macaque
asparaginyl-tRNA synthetase 2, mitochondrial
Mouse
Rat
Horse
asparaginyl-tRNA synthetase 2, mitochondrial
Publication Statistics
PubMed Score 67.94
PubMed score by year
PubTator Score 9.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title